Thursday, November 21, 2024 11/21/2024

Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies

Award Number: R35GM119707
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Project Summary Enzymes that employ transition metals can initiate chemically challenging modifications of inert chemical bonds. These systems serve as both important drug targets and useful biocatalysts. In certain transition-metal driven essential biological transformations, such as DNA biosynthesis, divergent trace elements can be used for reaction initiation. Discovery of novel metal cofactors used for these processes, and their mechanisms of assembly and deployment, will enable novel routes of enzyme inhibition in bacterial pathogens. In a second project, structures and reaction mechanisms in three different metalloenzyme superfamilies relevant to biocatalysis will be elucidated. These systems use a common cofactor to catalyze divergent reaction outcomes, controlled by structural features of each enzyme. A comparative approach provides detailed and testable hypotheses about the means by which distinct chemical reactions are accomplished, as well as discovery of entirely new families of enzymes and new ways to control their activities. The objective of this work is to enable exploitation of the catalytic power inherent in these systems for more efficient and environmentally friendly synthesis of drugs, chemicals, technological tools, and new chemical processes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	9	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $439,730 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	9	5/9/2024	SUPPLEMENT FOR EXPANSION	$19,582
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	9	5/8/2024	NON-COMPETING CONTINUATION	$420,148
														Subtotal = $439,730

Issue Date FY: 2023 ( Subtotal = $484,365 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	002	8	5/19/2023	SUPPLEMENT FOR EXPANSION	$71,845
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	8	5/18/2023	NON-COMPETING CONTINUATION	$420,532
2023	2020	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	5	2/2/2023	NON-COMPETING CONTINUATION	-$8,012
														Subtotal = $484,365

Issue Date FY: 2022 ( Subtotal = $479,652 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	7	5/13/2022	NON-COMPETING CONTINUATION	$420,906
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	003	7	8/25/2022	SUPPLEMENT FOR EXPANSION	$58,746
2022	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	002	6	5/20/2022	COMPETING CONTINUATION	$41,190
2022	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	5	5/20/2022	NON-COMPETING CONTINUATION	-$41,190
														Subtotal = $479,652

Issue Date FY: 2021 ( Subtotal = $421,268 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	6	5/18/2021	COMPETING CONTINUATION	$421,268
2021	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	5	5/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $421,268

Issue Date FY: 2020 ( Subtotal = $385,717 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	5	5/20/2020	NON-COMPETING CONTINUATION	$385,717
														Subtotal = $385,717

Issue Date FY: 2019 ( Subtotal = $635,564 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	4	8/22/2019	SUPPLEMENT FOR EXPANSION	$249,600
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	4	5/22/2019	NON-COMPETING CONTINUATION	$385,964
														Subtotal = $635,564

Issue Date FY: 2018 ( Subtotal = $386,202 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	3	5/17/2018	NON-COMPETING CONTINUATION	$386,202
														Subtotal = $386,202

Issue Date FY: 2017 ( Subtotal = $386,431 )
2017	2017	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	2	5/25/2017	NON-COMPETING CONTINUATION	$386,431
														Subtotal = $386,431

Issue Date FY: 2016 ( Subtotal = $376,836 )
2016	2016	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	8/1/2016	NEW	$376,836
														Subtotal = $376,836

Grand Total All Awards = $3,995,765

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies

Award Number: R35GM119707

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer