Thursday, December 26, 2024 12/26/2024

Methods for Selective Organic Synthesis based on Ionic Catalysts

Award Number: R35GM118190
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new reactions for the enantioselective construction of C-O, C-N and C-halogen bonds are proposed. Particular emphasis is placed on the development of methods for the selective introduction of fluorine and fluorine-containing functional groups. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will leverage new catalyst platforms, based on gold(III) complexes and phosphoric acid-based chiral anions, for the construction of fluorinated building blocks and heterocycles Additionally, the mechanistic underpinnings of these reactions will be studied, with a focus on uncovering the role of non-covalent interactions in achieving selectivity. Thus, we anticipate that this program will provide synthetic chemists and biomedical researchers with additional tools (reactions, catalysts, ligands etc.) for molecular synthesis and for single enantiomer construction, as well as provide principles for further development and application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	9	11/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $609,196 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	9	7/2/2024	NON-COMPETING CONTINUATION	$609,196
														Subtotal = $609,196

Issue Date FY: 2023 ( Subtotal = $609,196 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	8	5/18/2023	NON-COMPETING CONTINUATION	$609,196
														Subtotal = $609,196

Issue Date FY: 2022 ( Subtotal = $713,595 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	7	6/13/2022	NON-COMPETING CONTINUATION	$463,595
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	7	6/14/2022	SUPPLEMENT FOR EXPANSION	$250,000
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	6	12/3/2021	COMPETING CONTINUATION	$279,784
2022	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	12/3/2021	NON-COMPETING CONTINUATION	-$279,784
														Subtotal = $713,595

Issue Date FY: 2021 ( Subtotal = $629,722 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	6	7/16/2021	SUPPLEMENT FOR EXPANSION	$20,958
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	6	5/28/2021	COMPETING CONTINUATION	$608,764
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	5/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $629,722

Issue Date FY: 2020 ( Subtotal = $713,087 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	4	12/6/2019	SUPPLEMENT FOR EXPANSION	$51,331
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	5	5/1/2020	NON-COMPETING CONTINUATION	$661,756
														Subtotal = $713,087

Issue Date FY: 2019 ( Subtotal = $559,417 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	4	6/7/2019	NON-COMPETING CONTINUATION	$559,417
														Subtotal = $559,417

Issue Date FY: 2018 ( Subtotal = $660,326 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	002	3	9/12/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	001	3	9/3/2018	SUPPLEMENT FOR EXPANSION	$100,000
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	3	5/11/2018	NON-COMPETING CONTINUATION	$560,326
														Subtotal = $660,326

Issue Date FY: 2017 ( Subtotal = $560,326 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	2	5/22/2017	NON-COMPETING CONTINUATION	$560,326
														Subtotal = $560,326

Issue Date FY: 2016 ( Subtotal = $489,596 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	1	6/3/2016	NEW	$489,596
														Subtotal = $489,596

Grand Total All Awards = $5,544,461

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Methods for Selective Organic Synthesis based on Ionic Catalysts

Award Number: R35GM118190

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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