Friday, January 3, 2025 1/3/2025

Genomics of rapid adaptation in the lab and in the wild

Award Number: R35GM118165
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Adaptation is the foundational concept in biology. My lab aims to build an empirically and theoretically rich theory of adaptation. We focus specifically on the inference of adaptation from genomic data and on the study of rapid evolution in real time. The latter include (i) experimental evolution in yeast (adaptation by de novo mutation in well-mixed clonal system), (ii) adaptation on seasonal and ecological time-scales in Drosophila (adaptation from standing variation in a obligately sexual organism), and (iii) tumor initiation, growth, and evolution in experimental mouse model of lung cancer (engineered de novo and spontaneous alterations in a spatially constrained context). These projects utilize a diversity of systems, high throughput and well-powered experimental modalities, and sophisticated and varied analytic frameworks, but they all focus on the overarching need to understand the dynamics of rapid adaptation. Ultimately, we aim to construct a theory of evolutionary adaptation that can naturally account for the patterns of evolution established over long periods of time, which are evident in genomic data, as well as the short-term dynamics of adaptation directly observable in short-term experimental studies of evolution.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	9	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $725,021 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	9	5/10/2024	NON-COMPETING CONTINUATION	$725,021
														Subtotal = $725,021

Issue Date FY: 2023 ( Subtotal = $974,849 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	8	5/22/2023	NON-COMPETING CONTINUATION	$725,021
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	8	8/7/2023	SUPPLEMENT FOR EXPANSION	$249,828
														Subtotal = $974,849

Issue Date FY: 2022 ( Subtotal = $725,021 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	004	7	5/13/2022	NON-COMPETING CONTINUATION	$725,021
2022	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	003	6	11/18/2021	COMPETING CONTINUATION	$14,823
2022	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	6	11/10/2021	COMPETING CONTINUATION	-$16,589
2022	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	5	11/10/2021	NON-COMPETING CONTINUATION	$16,589
2022	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	002	5	11/18/2021	NON-COMPETING CONTINUATION	-$14,823
														Subtotal = $725,021

Issue Date FY: 2021 ( Subtotal = $725,021 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	6	5/27/2021	COMPETING CONTINUATION	$725,021
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	002	6	9/10/2021	COMPETING CONTINUATION	$16,589
2021	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	5	9/10/2021	NON-COMPETING CONTINUATION	-$16,589
														Subtotal = $725,021

Issue Date FY: 2020 ( Subtotal = $705,244 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	5	5/7/2020	NON-COMPETING CONTINUATION	$705,244
														Subtotal = $705,244

Issue Date FY: 2019 ( Subtotal = $706,034 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	4	6/3/2019	NON-COMPETING CONTINUATION	$706,034
														Subtotal = $706,034

Issue Date FY: 2018 ( Subtotal = $831,034 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	3	5/29/2018	NON-COMPETING CONTINUATION	$706,034
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	3	9/14/2018	SUPPLEMENT FOR EXPANSION	$125,000
														Subtotal = $831,034

Issue Date FY: 2017 ( Subtotal = $707,614 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	2	5/29/2017	NON-COMPETING CONTINUATION	$707,614
														Subtotal = $707,614

Issue Date FY: 2016 ( Subtotal = $712,354 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	5/27/2016	NEW	$712,354
														Subtotal = $712,354

Grand Total All Awards = $6,812,192

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Genomics of rapid adaptation in the lab and in the wild

Award Number: R35GM118165

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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