Wednesday, May 1, 2024 5/1/2024

Assembly and function of cytoskeletal systems in eukaryotic and prokaryoticcells

Award Number: R35GM118119
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Project Summary/Abstract My laboratory pursues answers to fundamental questions in cell biology. Broadly, we study how self-assembly of complex macromolecular structures —especially cytoskeletal polymers and networks— creates spatial order in living cells. To understand how molecular properties govern the architecture and function of living cells, we perform quantitative studies at multiple size scales: (i) single-molecule and bulk biochemical studies of cytoskeletal components; (ii) biophysical and microscopical studies of complex cellular structures reconstituted in vitro; and (iii) cell biological and high-resolution microscopy studies of cytoskeletal systems in living cells. Our work currently addresses the following topics: (1) function and regulation of actin network motors that make use of the Arp2/3 complex; (2) pseudopod assembly and amoeboid locomotion; (3) autophagy and endomembrane movement; (4) nuclear actin assembly and DNA repair; and (5) assembly and function of cytoskeletal elements in eubacteria and archaea. As part of an international consortium we have also recently begun work to understand how SARS-CoV2 induces formation of long, branched filopodia in infected host cells and what function these filopodia play in viral egress and spread.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $436,050 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	9	3/8/2024	NON-COMPETING CONTINUATION	$436,050
														Subtotal = $436,050

Issue Date FY: 2023 ( Subtotal = $483,270 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	8	3/17/2023	NON-COMPETING CONTINUATION	$484,500
2023	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	2/2/2023	NON-COMPETING CONTINUATION	-$1,230
														Subtotal = $483,270

Issue Date FY: 2022 ( Subtotal = $484,500 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	7	3/21/2022	NON-COMPETING CONTINUATION	$436,050
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	7	7/12/2022	NON-COMPETING CONTINUATION	$48,450
														Subtotal = $484,500

Issue Date FY: 2021 ( Subtotal = $484,500 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	003	6	8/13/2021	COMPETING CONTINUATION	$11,441
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	6	4/6/2021	COMPETING CONTINUATION	$484,500
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	4/5/2021	NON-COMPETING CONTINUATION	$0
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	002	5	8/13/2021	NON-COMPETING CONTINUATION	-$11,441
														Subtotal = $484,500

Issue Date FY: 2020 ( Subtotal = $475,500 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	3/27/2020	NON-COMPETING CONTINUATION	$475,500
														Subtotal = $475,500

Issue Date FY: 2019 ( Subtotal = $475,500 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	4	3/26/2019	NON-COMPETING CONTINUATION	$475,500
														Subtotal = $475,500

Issue Date FY: 2018 ( Subtotal = $475,500 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	3	5/18/2018	NON-COMPETING CONTINUATION	$47,550
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	3	3/13/2018	NON-COMPETING CONTINUATION	$427,950
														Subtotal = $475,500

Issue Date FY: 2017 ( Subtotal = $475,500 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	2	8/3/2017	NON-COMPETING CONTINUATION	$47,550
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	2	3/16/2017	NON-COMPETING CONTINUATION	$427,950
														Subtotal = $475,500

Issue Date FY: 2016 ( Subtotal = $475,500 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	1	4/15/2016	NEW	$475,500
														Subtotal = $475,500

Grand Total All Awards = $4,265,820

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Assembly and function of cytoskeletal systems in eukaryotic and prokaryoticcells

Award Number: R35GM118119

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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