Tuesday, January 6, 2026 1/6/2026

Structural studies of viral replication and invasion

Award Number: R35GM118047
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2016
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Structural studies of viral replication and invasion - Abstract Viruses are a major threat to human health. Our laboratory uses various structural biology techniques to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. One area of our major interest is retroviral integration, a critical step in the lifecycle of retroviruses that achieves permanent insertion of the reverse-transcribed viral genome into a host chromosome. We will build on our recent structural studies of the Human T-cell Leukemia virus and Rous sarcoma virus intasomes and further investigate the roles of host factors during integration of these retroviruses. Another area that we are pursuing is the replication of coronavirus RNA genomes and host cell invasion. In particular, we are interested in how a virally encoded exoribonuclease complex facilitates faithful replication of the large RNA genomes of coronaviruses, and how this unique proofreading activity could be modulated by small molecules. We are also investigating inhibition of the receptor binding of the coronavirus spike protein by novel antibodies and antibody-mimics. Overall, the studies proposed in this application will help better understand important RNA-based human pathogens and could aid in the development of antiviral strategies, or alternatively, gene delivery tools useful in research or gene therapy applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $557,682 )
2026	2026	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Biomedical Research and Research Training	000	10	12/11/2025	NON-COMPETING CONTINUATION	$557,682
														Subtotal = $557,682

Issue Date FY: 2025 ( Subtotal = $619,646 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	9	12/6/2024	NON-COMPETING CONTINUATION	$557,682
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Biomedical Research and Research Training	002	9	8/12/2025	NON-COMPETING CONTINUATION	$61,964
2025	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	8	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $619,646

Issue Date FY: 2024 ( Subtotal = $790,435 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	002	8	6/19/2024	NON-COMPETING CONTINUATION	$61,964
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	8	6/4/2024	SUPPLEMENT FOR EXPANSION	$170,789
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	8	12/8/2023	NON-COMPETING CONTINUATION	$557,682
														Subtotal = $790,435

Issue Date FY: 2023 ( Subtotal = $619,646 )
2023	2023	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	7	12/21/2022	NON-COMPETING CONTINUATION	$557,682
2023	2023	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	7	2/20/2023	NON-COMPETING CONTINUATION	$61,964
														Subtotal = $619,646

Issue Date FY: 2022 ( Subtotal = $619,646 )
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	6	12/27/2021	COMPETING CONTINUATION	$619,646
2022	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	5	12/17/2021	NON-COMPETING CONTINUATION	$0
2022	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	002	5	7/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $619,646

Issue Date FY: 2020 ( Subtotal = $619,646 )
2020	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	5	6/24/2020	NON-COMPETING CONTINUATION	$619,646
														Subtotal = $619,646

Issue Date FY: 2019 ( Subtotal = $619,646 )
2019	2019	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	4	7/1/2019	NON-COMPETING CONTINUATION	$619,646
														Subtotal = $619,646

Issue Date FY: 2018 ( Subtotal = $619,646 )
2018	2018	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	3	6/28/2018	NON-COMPETING CONTINUATION	$619,646
														Subtotal = $619,646

Issue Date FY: 2017 ( Subtotal = $616,134 )
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	2	7/3/2017	NON-COMPETING CONTINUATION	$616,134
														Subtotal = $616,134

Issue Date FY: 2016 ( Subtotal = $532,598 )
2016	2016	UNIVERSITY OF MINNESOTA, OFFICE OF STUDENT FINANCE AID	106 PLEASANT SE, 210 FRASER HL	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	1	6/30/2016	NEW	$532,598
														Subtotal = $532,598

Grand Total All Awards = $6,214,725

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Structural studies of viral replication and invasion

Award Number: R35GM118047

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2016

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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