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Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer

Award Number: R35CA253095
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/21/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer - ABSTRACT Innate immune sensors and inflammasomes drive an immune response, primarily providing protection against microbial infections and mediating control over sterile insults. However, aberrant innate immune signaling is associated with the pathogenesis of several inflammatory and metabolic diseases, neurodegeneration, and cancer. In the United States, colorectal cancer is the second most common cause of cancer deaths. Innate immunity is a major player in the colon, and thus understanding how innate immune pathways contribute to the various stages of tumor development will be key to improving cancer treatment strategies. We have an extensive track record of discoveries related to innate immune sensors and their role in colitis-associated colorectal cancer. We now seek to continue and expand this research program. The primary focus of this application is to unravel the key mechanisms of novel innate immune sensors and inflammasome regulators discovered in our lab recently and their crosstalk with cell death regulators in the development of colorectal cancer. Basic science supporting this area of research is critical to understanding the fundamentals of innate immune responses. This understanding lays the foundation to explain how defects in these sensing systems lead to the development of disease in humans. Moreover, as the molecules we are studying are central drug targets, our studies will be translated into the development of new therapeutics to treat several devastating diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,077,000 )
2025	2025	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	6	6/26/2025	NON-COMPETING CONTINUATION	$1,077,000
														Subtotal = $1,077,000

Issue Date FY: 2024 ( Subtotal = $1,023,150 )
2024	2024	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	001	5	9/9/2024	NON-COMPETING CONTINUATION	$1,023,150
2024	2023	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	4	9/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,023,150

Issue Date FY: 2023 ( Subtotal = $1,055,460 )
2023	2023	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	4	8/1/2023	NON-COMPETING CONTINUATION	$1,055,460
														Subtotal = $1,055,460

Issue Date FY: 2022 ( Subtotal = $1,008,812 )
2022	2022	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	3	6/2/2022	NON-COMPETING CONTINUATION	$1,008,812
														Subtotal = $1,008,812

Issue Date FY: 2021 ( Subtotal = $1,077,000 )
2021	2021	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	2	6/30/2021	NON-COMPETING CONTINUATION	$1,077,000
														Subtotal = $1,077,000

Issue Date FY: 2020 ( Subtotal = $721,739 )
2020	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	1	7/21/2020	NEW	$721,739
														Subtotal = $721,739

Grand Total All Awards = $5,963,161

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Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer

Award Number: R35CA253095

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/21/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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