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Making cancer precision medicine real: bottlenecks and opportunities

Award Number: R35CA242457
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Making cancer precision medicine real: bottlenecks and opportunities - PROJECT SUMMARY The concept of cancer precision medicine is simple: patient treatments are guided by the molecular features of their tumor. In practice, however, the situation is more complex. Only a minority of patients at present benefit from the approach. A number of scientific challenges must be overcome before cancer precision medicine can become a reality for all patients. These challenges are the focus on the present research proposal. For example, we now know that gene expression, not DNA-level aberrations, are the most predictive of drug response, and yet the entire clinical genomic testing enterprise is focused on DNA. We therefore need to develop methods suitable for quantitative RNA-based diagnostics, likely using emerging single cell and in situ sequencing methods. In addition, we must develop comprehensive maps using preclinical models that make it possible to predict drug sensitivity (and genetic vulnerabilities) given the molecular features of the tumor. This will require expanding our repertoire of cell models (to include organoids, short-term primary tumor cultures and models that combine tumor cells and immune cells), developing more sophisticated read-outs of drug action beyond viability, and also developing new insights into the influence of the tumor microenvironment on mediating cell survival and drug resistance. The present proposal aims to address these challenges over the 7 years ahead by developing new methods and datasets that will accelerate cancer precision medicine research throughout the research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,023,754 )
2025	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	7	7/17/2025	NON-COMPETING CONTINUATION	$1,023,754
														Subtotal = $1,023,754

Issue Date FY: 2024 ( Subtotal = $972,460 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	6	9/6/2024	NON-COMPETING CONTINUATION	$972,460
														Subtotal = $972,460

Issue Date FY: 2023 ( Subtotal = $1,003,799 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	5	9/7/2023	NON-COMPETING CONTINUATION	$1,003,799
														Subtotal = $1,003,799

Issue Date FY: 2022 ( Subtotal = $1,003,803 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	4	8/19/2022	NON-COMPETING CONTINUATION	$1,003,803
														Subtotal = $1,003,803

Issue Date FY: 2021 ( Subtotal = $844,357 )
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	3	8/23/2021	NON-COMPETING CONTINUATION	$844,357
														Subtotal = $844,357

Issue Date FY: 2020 ( Subtotal = $1,024,290 )
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	001	2	8/24/2020	NON-COMPETING CONTINUATION	$1,024,290
2020	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	1	3/23/2020	NEW	$0
														Subtotal = $1,024,290

Issue Date FY: 2019 ( Subtotal = $1,024,290 )
2019	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Biology Research	000	1	9/16/2019	NEW	$1,024,290
														Subtotal = $1,024,290

Grand Total All Awards = $6,896,753

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Making cancer precision medicine real: bottlenecks and opportunities

Award Number: R35CA242457

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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