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Development and Evaluation of an Indigenized Family Acceptance Project for Lakota LGBTQ2S+ Youth

Award Number: R34MH134937
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/12/2026
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Development and Evaluation of an Indigenized Family Acceptance Project for Lakota LGBTQ2S+ Youth - Project Summary Indigenous LGBTQ2S+ youth experience disproportionately high rates of depression, anxiety, suicidality, substance use, and violence exposure, yet there are very few culturally grounded, family- based interventions designed to support their mental health and well-being. The parent award supports the cultural adaptation and pilot evaluation of the Family Acceptance Project (FAP) for Lakota LGBTQ2S+ youth ages 13 to 18 and their caregivers in Rapid City, South Dakota and on the Pine Ridge Reservation. This project adapts the evidence informed FAP model to align with Lakota cultural teachings and community priorities through partnerships with Lakota youth, caregivers, Elders, and Traditional Knowledge Keepers. Using an Indigenized ADAPT-ITT process, the study refines the intervention through advisory boards, theatre testing, and an open pilot trial with Lakota families. The project then evaluates feasibility, acceptability, and preliminary signals of impact through a pilot randomized controlled trial comparing traditional FAP, Indigenized FAP, and wait-list control condition. As the study transitions into the randomized trial phase, implementation of the open pilot phase has demonstrated that greater clinical safety infrastructure is required than originally anticipated to responsibly recruit and support youth and families participating in the study. Indigenous LGBTQ2S+ youth who experience family conflict or rejection related to sexual orientation or gender identity may also face elevated mental health risks, including suicidality and acute distress. Ensuring participant safety therefore requires licensed clinical oversight for screening, suicide risk assessment, safety planning, crisis response, and coordination with community behavioral health services. The requested administrative supplement will support implementation of clinical safety procedures that are already required by the approved protocol and oversight plan. These activities include clinical follow-up during screening, consultation during program delivery, follow-up for participants who endorse suicidality on study measures, and supervision of research staff assisting with safety monitoring. The supplement will provide the clinical and administrative capacity needed to implement these procedures as recruitment expands for the pilot randomized controlled trial. These activities remain fully within the scope of the parent award and are essential to ensuring participant safety and preserving the ethical and scientific integrity of this culturally grounded intervention study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $273,682 )
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health Research Grants	001	3	9/3/2026	SUPPLEMENT FOR EXPANSION	$65,295
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health Research Grants	000	3	2/10/2026	NON-COMPETING CONTINUATION	$208,387
														Subtotal = $273,682

Issue Date FY: 2025 ( Subtotal = $228,430 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health Research Grants	001	2	7/16/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$228,430
2025	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Mental Health Research Grants	000	1	7/16/2025	NEW	$0
2025	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Mental Health Research Grants	002	1	9/25/2025	NEW	$0
														Subtotal = $228,430

Issue Date FY: 2024 ( Subtotal = $233,250 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST	LINCOLN	NE	68503	LANCASTER	USA	Mental Health Research Grants	000	1	3/8/2024	NEW	$233,250
														Subtotal = $233,250

Grand Total All Awards = $735,362

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Development and Evaluation of an Indigenized Family Acceptance Project for Lakota LGBTQ2S+ Youth

Award Number: R34MH134937

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/12/2026

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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