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Development of an Integrated Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder in Pregnancy

Award Number: R34AA033186
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Development of an Integrated Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder in Pregnancy - ABSTRACT The long-term goal of this research is to treat alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) by applying an efficient integrated intervention tailored for delivery during pregnancy. Despite substantial maternal and infant risks associated with AUD and PTSD, there are significant gaps in research and clinical knowledge on treating these conditions in pregnancy. Further, there are individual and system level challenges to patients' engagement in maternal behavioral health care for AUD and PTSD. There is an imperative need for an accessible and scalable integrated treatment model for AUD and PTSD tailored for delivery during pregnancy. This study will adapt an integrated intervention called Skills Training and Exposure for PTSD and Substance Use for Pregnancy (STEPS-P). STEPS-P uses Cognitive Behavioral Therapy for AUD and Written Exposure therapy for PTSD, two widely used approaches with strong evidence. First, qualitative data will be collected from providers and patients to refine the integrated intervention for delivery during pregnancy. Next, we will examine the feasibility and acceptability of the tailored intervention delivered via telehealth. A randomized controlled pilot study will be completed with 40 pregnant women recruited from the community and obstetric clinics who report AUD and PTSD and meet other eligibility criteria (e.g., heavy drinking during the 60 days prior to positive pregnancy test). Participants will be randomized in a 2:1 manner to one of two conditions: 1) five sessions of STEPS-P plus two booster sessions delivered via telehealth; 2) Treatment As Usual. Assessments will be conducted at baseline, post-intervention, 1-month post-intervention during the prenatal period, 1-, 2-, and 4- months postpartum. Exit interviews will be completed with participants assigned to STEPS-P to further refine the intervention. Primary outcomes will be feasibility of research methods (e.g., % enrolled, retained) and acceptability of STEPS-P. Primary clinical outcomes will focus on both alcohol (time to first postpartum drink, time to first postpartum heavy drinking day, percent days drinking, percent heavy drinking days, and average drinks per drinking day) and PTSD (clinician-rated and self-report symptom severity and diagnostic status). Secondary outcomes will include ethyl glucuronide biomarkers, alcohol craving, perinatal depression, gestational age, birth weight, and infant-mother bonding. Results should advance scientific knowledge of feasible methods for conducting clinical trial research on the treatment of AUD and PTSD during pregnancy and provide preliminary data needed to support a larger randomized controlled trial testing the proposed novel integrated intervention for pregnancy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $179,313 )
2026	2026	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	1	9/11/2026	NEW	$179,313
														Subtotal = $179,313

Grand Total All Awards = $179,313

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Development of an Integrated Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder in Pregnancy

Award Number: R34AA033186

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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