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Engaging the subgenual cingulate with brain stimulation for depression

Award Number: R33MH135428
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Engaging the subgenual cingulate with brain stimulation for depression - ABSTRACT The subgenual anterior cingulate cortex (sgACC) has dominated the literature utilizing repetitive transcranial magnetic stimulation (rTMS) to treat depression for good reason: treatment focusing on the frontal-sgACC brain circuit is effective and changes in resting fMRI connectivity with the sgACC accompany symptom improvements. However, it has not yet been proven that TMS actually engages the sgACC which would support continued focus on this circuit at the exclusion of other potential targets from the fMRI literature. With the application of interleaved TMS/fMRI, it is possible to capture brain responses caused by TMS to any brain surface site. Using resting fMRI connectivity to guide TMS targeting, we seek to establish neuromodulation of the sgACC pathway (R61, Aim 1) and the best connectivity pipeline for robustly engaging the sgACC (R61, Aim 2). Upon establishing these successful benchmarks, the R33 phase will demonstrate that the sgACC evoked response at baseline predicts depression improvement when treatment delivered to this same circuit (R33, Aim1). To cement the relationship between modulation of the frontal-sgACC circuit with treatment and depression improvement, we hypothesize an association between brain changes and clinical changes (R33, Aim 2). We hypothesize that the R33 clinical associations with evoked brain responses will be established for active but not for sham rTMS. Together, this research will elucidate basic mechanisms of rTMS treatment that will accelerate brain circuit targeted neurotherapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,396,404 )
2026	2026	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	3	7/8/2026	EXTENSION WITH OR WITHOUT FUNDS	$1,396,404
														Subtotal = $1,396,404

Grand Total All Awards = $1,396,404

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Engaging the subgenual cingulate with brain stimulation for depression

Award Number: R33MH135428

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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