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Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias

Award Number: R33AG078084
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias - PROJECT SUMMARY Delaying the onset of Alzheimer’s disease and related dementias (ADRD) by even a few years could amass substantial improvements in quality of life for individuals and families, independent living, and the cost of specialized healthcare. Positive cognitive outcomes associated with physical activity interventions conducted in middle-aged and older adults have increased the promise that primary prevention of ADRD may be achievable via lifestyle change. It may take years to decades of adherence to health promoting behaviors to realize appreciable gains in cognitive health span. Critically, while lifestyle interventions are supportive of behavior change in the short-term, longer-term maintenance of cognitive health promoting behaviors (i.e. continued enactment of these behaviors 6+ months after completion of the intervention) has proven difficult to achieve. The current project will leverage an mHealth approach using commercially-available technology (smart phones, wrist-worn activity monitors) to promote long-term maintenance of light intensity physical activity (LIPA) in middle-aged adults at increased risk for ADRD (adults with obesity). Following a health education session with a certified exercise physiologist, our approach will deliver the other intervention components: adaptive daily step goal setting (both arms), self-monitoring (both arms), and interim goal setting every 2-3 hours (treatment arm-only), on study smart phones, over the course of participants daily lives. We aim to demonstrate that the interim goal setting manipulation to the intervention can lead to greater long-term maintenance of LIPA by keeping LIPA goals active in the focus attention during each day of the intervention period and increasing LIPA self-efficacy through regular goal attainment. Goal maintenance (indicated by self- monitoring frequency) will be quantified via participant interactions with custom-integrated Fitbit wrist-worn activity monitors and the Mobile Monitoring of Cognitive Change (M2C2) component of the forthcoming NIH Mobile Toolbox. Fitbits will be configured with a custom-designed clockface that displays accumulated step counts when a ‘check my steps’ button is pressed. Logging and timestamping these interactions will allow for quantification of self-monitoring frequency. We propose that development of these adherence-promoting mechanisms (goal maintenance and self-efficacy) can act as a self-regulatory scaffold from which long-term health promotion gains can be realized. The current project will: 1) demonstrate the ability of interim goal setting to engage our proposed adherence-promoting targets (Aim 1); 2) test the efficacy of the interim goal setting manipulation to increase short- and long-term LIPA maintenance following the intervention through goal maintenance and increased self-efficacy (Aim 2); 3) examine how variation in cognition influences the ability of the intervention to engage goal maintenance (Aim 3); 4) explore the long-term salutary effects of the intervention on cognitive (change in ADRD risk) and physical health (change in weight, V02-max; Aim 4).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $765,320 )
2026	2026	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	000	5	5/26/2026	NON-COMPETING CONTINUATION	$765,320
														Subtotal = $765,320

Issue Date FY: 2025 ( Subtotal = $762,261 )
2025	2025	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	000	4	7/14/2025	NON-COMPETING CONTINUATION	$762,261
														Subtotal = $762,261

Issue Date FY: 2024 ( Subtotal = $901,531 )
2024	2024	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	002	3	6/2/2024	NON-COMPETING CONTINUATION	$796,682
2024	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	000	2	10/23/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	001	2	2/22/2024	EXTENSION WITH OR WITHOUT FUNDS	$104,849
														Subtotal = $901,531

Issue Date FY: 2023 ( Subtotal = $810,386 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	001	2	8/23/2023	EXTENSION WITH OR WITHOUT FUNDS	$15,659
2023	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	000	2	8/22/2023	EXTENSION WITH OR WITHOUT FUNDS	$711,510
2023	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	003	2	9/12/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2023	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Aging Research	002	2	9/1/2023	EXTENSION WITH OR WITHOUT FUNDS	$83,217
														Subtotal = $810,386

Grand Total All Awards = $3,239,498

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Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias

Award Number: R33AG078084

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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