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ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

Award Number: R33AG070455
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY - In direct response to PA-23-054, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies, we propose continued development and utilization of the CALERIE Research Network to inform aging biology. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™ Phase 2) was a randomized controlled trial designed to assess the effects in humans of two years of sustained caloric restriction (CR) without enforced changes of dietary composition. The overall objective was to elucidate underlying biological mechanisms and mediators of primary and secondary human aging. The rigorous design and execution of the CALERIE intervention produced an invaluable resource, including comprehensive phenotypic data that are coupled to biological samples. During the current period of R33 support, we have promoted and stewarded use of CALERIE samples and data, resulting in landmark publications by both experienced and early career scientists and expansion of CALERIE “omics” data. We have used our CALERIE Scholars and Pilot Projects Programs to grow the ranks of early career investigators who are dedicated to advancing aging biology. Here, we propose to 1) ensure continued use of CALERIE samples and data and 2) grow the Network through incorporation of samples and data from the CALERIE Legacy Study (a fifteen-year follow-up of CALERIE Phase 2 participants) and two recently completed CR pilot projects (Healthy Aging and Late Life Outcomes Planning [HALLO-P] and (Dietary Approaches to Longevity and Health (DiAL Health). Our infrastructure will benefit from an established Steering Committee (SC) that includes an NIA Biobank representative and growth of the SC to include a mid-career scientist with unique expertise in integrating complex data and developing novel aging metrics. We will foster scientific synergy through biennial workshops, monthly working group meetings, and the CALERIE Scholars Program, which provides direct and indirect mentoring for early career scientists. Leveraging the growth of data, two novel additions are to 1) develop and deploy multi-level, multi-omics databases to gain insight into the complexities of aging biology and 2) use machine learning causal modeling methodology to derive insights into molecular mechanisms of CR, drug targets that mimic CR benefits, and targets that mitigate CR adverse effects. Through activities to promote inter-disciplinary collaborations, develop and support established and emerging investigators, integrate multiple data types, and expand data analysis complexity, this renewal grant will augment the data and sample repositories, perpetuate the aging biology scientific cycle, and advance understanding of human aging biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $642,802 )
2026	2026	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	002	6	4/1/2026	COMPETING CONTINUATION	$642,802
2026	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	001	5	3/2/2026	NON-COMPETING CONTINUATION	$0
2026	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	5	1/14/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $642,802

Issue Date FY: 2025 ( Subtotal = $617,168 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	5	3/17/2025	NON-COMPETING CONTINUATION	$566,788
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	001	5	6/10/2025	NON-COMPETING CONTINUATION	$50,380
														Subtotal = $617,168

Issue Date FY: 2024 ( Subtotal = $636,324 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	002	4	6/11/2024	NON-COMPETING CONTINUATION	$63,632
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	001	4	5/3/2024	NON-COMPETING CONTINUATION	$0
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	4	1/25/2024	NON-COMPETING CONTINUATION	$572,692
														Subtotal = $636,324

Issue Date FY: 2023 ( Subtotal = $642,884 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	3	4/28/2023	NON-COMPETING CONTINUATION	$642,884
														Subtotal = $642,884

Issue Date FY: 2022 ( Subtotal = $757,501 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Aging Research	000	2	3/4/2022	NON-COMPETING CONTINUATION	$597,864
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Aging Research	001	2	5/5/2022	NON-COMPETING CONTINUATION	$66,431
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Aging Research	002	2	7/1/2022	SUPPLEMENT FOR EXPANSION	$93,206
														Subtotal = $757,501

Issue Date FY: 2021 ( Subtotal = $723,241 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Aging Research	000	1	2/10/2021	NEW	$723,241
														Subtotal = $723,241

Grand Total All Awards = $4,019,920

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ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

Award Number: R33AG070455

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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