Tuesday, August 12, 2025 8/12/2025

Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's disease

Award Number: R33AG067916
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2027

Group Awards By:

View Award Description

Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's disease - Project Summary Alzheimer’s disease (AD) is a neurodegenerative disorder and the primary cause of dementia in the elderly and there is no cure currently available. Necroptosis is a complex and regulated caspase-independent cell death mechanism mediated by various protein members, e.g. receptor-interacting protein kinase 1 (RIP1 or RIPK1) involving inflammation. Notably, RIPK1 is up-regulated by microglial cells in human AD brains and mediates a disease-associated microglial response in AD. Unfortunately, there are no suitable non-invasive neuroimaging tools for investigating these processes in animals or in man. The development of a biomarker for visualizing RIPK1 in vivo represents a key step in understanding both the normal function and pathophysiology of RIPK1 in brain. Moreover, these techniques will accelerate the discovery of small molecule therapeutics that selectively interacts with RIPK1. The project is designed to validate a novel PET imaging probe for RIPK1 imaging in rodents and non-human primates during the R61 phase and perform the first-in-human imaging in the R33 phase. The success of healthy control imaging in this grant period will lead to further imaging study in patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $791,560 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	000	4	8/6/2025	EXTENSION WITH OR WITHOUT FUNDS	$791,560
														Subtotal = $791,560

Grand Total All Awards = $791,560

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's disease

Award Number: R33AG067916

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer