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An Online Short-Course in Sample-Size Determination - A Practical Guide to Improving Reproducibility through Proper Planning

Award Number: R25GM132784
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Sample-size planning is currently the Achilles heel of biomedical research. Many fields of preclinical research routinely rely on inadequate samples, leading to waste, excessive false-positives, and inflated effect sizes. These practices persist because researchers often eschew sound sample-size planning for easy but invalid approaches. To help address this critical issue, this project will produce a self-guided online course that will help trainees exchange poor sample-size determination practices for sound approaches. The course will a) help redirect researchers away from erroneous approaches by making clear their severe negative consequences, b) will dispel common misconceptions that discourage sound sample-size planning, and c) will provide exercises with instant feedback to build self-efficacy for independent sample-size planning. The materials will be produced for a modest budget, will incorporate guidance from a team of renowned methodological experts, and will be anchored in a proven behavioral-change approach. The course will provide a needed supplement to current materials, which do not adequately teach sample-size determination. A thoughtful piloting plan will enable extensive feedback from diverse stakeholders to ensure strong impact not only on knowledge but also on attitudes and actual competency. Dissemination will be supported through partnerships with professional societies and the extensive social media reach of the participating guest lecturers. Funding this proposal can have a strong positive impact on rigor and reproducibility in preclinical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$34,712 )
2024	2020	DOMINICAN UNIVERSITY	7900 DIVISION ST	RIVER FOREST	IL	60305	COOK	USA	Biomedical Research and Research Training	001	2	12/3/2023	NON-COMPETING CONTINUATION	-$17,931
2024	2019	DOMINICAN UNIVERSITY	7900 DIVISION ST	RIVER FOREST	IL	60305	COOK	USA	Biomedical Research and Research Training	000	1	12/3/2023	NEW	-$16,781
														Subtotal = -$34,712

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	DOMINICAN UNIVERSITY	7900 W DIVISION ST	RIVER FOREST	IL	60305	COOK	USA	Biomedical Research and Research Training	000	2	4/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $17,931 )
2020	2020	DOMINICAN UNIVERSITY	7900 W DIVISION ST	RIVER FOREST	IL	60305	COOK	USA	Biomedical Research and Research Training	000	2	4/16/2020	NON-COMPETING CONTINUATION	$17,931
														Subtotal = $17,931

Issue Date FY: 2019 ( Subtotal = $49,901 )
2019	2019	DOMINICAN UNIVERSITY	7900 W DIVISION ST	RIVER FOREST	IL	60305	COOK	USA	Biomedical Research and Research Training	000	1	5/1/2019	NEW	$49,901
														Subtotal = $49,901

Grand Total All Awards = $33,120

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An Online Short-Course in Sample-Size Determination - A Practical Guide to Improving Reproducibility through Proper Planning

Award Number: R25GM132784

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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