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Production and Validation of monoclonal antibodies to enhance rigor and reproducibility in research vertebrate animal model

Award Number: R24OD038109
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Production and Validation of monoclonal antibodies to enhance rigor and reproducibility in research vertebrate animal model - Project Summary Animal models are critical for biomedical research. They allow us to rapidly test the importance of any gene for development or diseases. Advances in technology now allow us to reduce or eliminate protein expression in the entire animal or in selected tissue. Similarly, mutations in the coding sequence of a gene associated with a disease can be introduce in animal model to test if they are indeed responsible for the disease state. Antibodies are critical tools to study protein localization and function. They can be used to block a protein function, send it for degradation, immunoprecipitate partners associated with the protein to identify functional complexes. While companies have focused on developing antibodies to human proteins, and to a lesser extend to mouse proteins, there is a need for antibodies that recognize proteins in diverse animal models. Despite the close similarity of protein sequences between human and mouse, many antibodies do not cross react. In addition, some proteins that have been recently identified or studied have not been targeted. Here we propose to produce antibodies against selected proteins in mouse, and amphibian (Xenopus and Axolotl) to facilitate the work in these animal models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $490,145 )
2025	2025	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Infrastructure Programs	000	1	5/2/2025	NEW	$490,145
														Subtotal = $490,145

Grand Total All Awards = $490,145

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Production and Validation of monoclonal antibodies to enhance rigor and reproducibility in research vertebrate animal model

Award Number: R24OD038109

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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