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Transitioning GLYCAM-Web to a self-sustaining carbohydrate modeling service

Award Number: R24GM136984
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2024

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Transitioning GLYCAM-Web to a self-sustaining carbohydrate modeling service - Project Summary For over a decade, GLYCAM-Web (www.glycam.org) has provided the scientific community with a suite of online tools for simplifying the modeling of 3D structures of carbohydrates, glycoproteins, and their interactions with proteins. The highly plastic nature of oligosaccharides and the fact that they are typically branched means that they place unique demands on both software developers and users. This is exacerbated by their complex and archaic nomenclature. GLYCAM-web was developed by a team of people with a unique depth of expertise in carbohydrate chemistry and informatics, with the overarching goal of making carbohydrate modeling more accessible to scientists who either lack computational expertise, or whose familiarity with carbohydrates is limited. According to AWstats and in-house code GLYCAM-Web was visited by ~110,000 unique addresses and had ~11,000 PDB file downloads from 2016 to 2019. The downloads are usually associated with creating and viewing 3D structures of glycans and for offline modeling. We have included a detailed usage analysis in the Research Strategy to emphasize the significance of this resource to the NIGMS research community. The development of GLYCAM-Web has been primarily supported through an NIH NIGMS P41 grant held at the Complex Carbohydrate Research Center at the University of Georgia that has been continuously renewed since the 1990s. With the ending of the P41 program, we are not eligible for further support within the P41 program, and are seeking support that with enable us to transition GLYCAM-Web to a near self-sustaining resource whose operation costs are offset by new fee-for-service functionality targeting users who wish to perform molecular dynamics simulations, but who lack the expertise or infrastructure to do so. The decade- long development of GLYCAM-Web has seen the infrastructure grow and change with the advent of new architectures, code evolution, and increased security requirements, leading to a complex code base involving the C++, JAVA, and PYTHON languages. Thus a significant aspect of this proposal involves code refactoring to unify the code base, which will directly reduce maintenance costs. To achieve near self-sustainability, we have developed the four aims what will address the necessary improvements to code and infrastructure: usability, transferability, maintainability, and sustainability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	3	9/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $415,250 )
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	001	3	6/10/2022	NON-COMPETING CONTINUATION	$41,527
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	3	4/11/2022	NON-COMPETING CONTINUATION	$373,723
														Subtotal = $415,250

Issue Date FY: 2021 ( Subtotal = $490,750 )
2021	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	2	4/9/2021	NON-COMPETING CONTINUATION	$490,750
														Subtotal = $490,750

Issue Date FY: 2020 ( Subtotal = $528,500 )
2020	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	1	4/8/2020	NEW	$528,500
														Subtotal = $528,500

Grand Total All Awards = $1,434,500

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Transitioning GLYCAM-Web to a self-sustaining carbohydrate modeling service

Award Number: R24GM136984

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2024

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