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Fostering Scientific and Workforce Development by Maintaining and Enriching the CHAMACOS Birth Cohort

Award Number: R24ES028529
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Fostering Scientific and Workforce Development by Maintaining and Enriching the CHAMACOS Birth Cohort - ABSTRACT CHAMACOS is a longitudinal cohort study of Latino mothers and children from a California farmworker community who have been followed for more than 20 years to assess the impact of environmental exposures and social determinants on children’s health and development. CHAMACOS mothers were enrolled during pregnancy in 1999-2000; they and their children have been seen regularly since then. Over the past two decades, we have amassed a rich trove of behavioral, health, and exposure data from this cohort. Our active biorepository houses 330,000 biological (e.g. blood, urine, breastmilk, hair, saliva, teeth) and environmental samples (e.g. dust, allergens) that we continue to mine for new insights in environmental health. We also hold two decades’ worth of data on children’s neurodevelopment, lung function, physical growth, pubertal timing, cardiometabolic health, and psychosocial functioning and mental health into young adulthood. The cohort currently consists of almost 600 mothers (1st generation) and their 20-22 year old young adult children (2nd generation), some of whom have begun to have children themselves (3rd generation). We propose to begin data collection on the 3rd generation of participants, providing an unprecedented opportunity to assess, under future funding, multigenerational epigenetic effects of environmental exposure and social determinants in a well-characterized Latino cohort. Under the previous R24, we continued our strong community engagement that is vital to retention of the cohort; facilitated new research partnerships; improved our data sharing capabilities, protocols, and transparency through a web-portal; and maintained a strong Biorepository that is poised to address new research questions. In the next phase of this project, under the U24, we will expand on this important work by enriching our cohort with additional data on social determinants of health; laying the groundwork to enroll the 3rd generation of CHAMACOS participants; and promoting scientific and workforce diversity through collaborations with Hispanic-Serving Institutions and students and clinicians from Latino farmworker communities. We will expand resource sharing by making our data publicly available through an open-access data repository and promote sharing of biological and environmental samples through our web portal. Additionally, as the CHAMACOS founders move into retirement, we will transfer the leadership of the cohort to a new generation of investigators to ensure its continued, long-term success. This cohort represents a wealth of resources that should be maintained, enriched, and shared for future research opportunities. It has an engaged Latino participant population that allows scientific insight into an underserved population and provides opportunities to engage young Latino students, clinicians, and junior faculty to build the pipeline of future environmental health researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $381,094 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	119 CALIFORNIA HALL	BERKELEY	CA	94720	ALAMEDA	USA	Environmental Health	000	9	2/6/2026	NON-COMPETING CONTINUATION	$381,094
														Subtotal = $381,094

Issue Date FY: 2024 ( Subtotal = -$29 )
2024	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	5	12/12/2023	NON-COMPETING CONTINUATION	-$29
														Subtotal = -$29

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	5	12/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $290,464 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	5	7/13/2021	NON-COMPETING CONTINUATION	$290,464
														Subtotal = $290,464

Issue Date FY: 2020 ( Subtotal = $404,298 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	001	4	9/23/2020	SUPPLEMENT FOR EXPANSION	$113,834
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	4	6/22/2020	NON-COMPETING CONTINUATION	$290,464
														Subtotal = $404,298

Issue Date FY: 2019 ( Subtotal = $290,464 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Environmental Health	000	3	6/24/2019	NON-COMPETING CONTINUATION	$290,464
														Subtotal = $290,464

Issue Date FY: 2018 ( Subtotal = $290,464 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Environmental Health	000	2	7/6/2018	NON-COMPETING CONTINUATION	$290,464
														Subtotal = $290,464

Issue Date FY: 2017 ( Subtotal = $310,919 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Environmental Health	000	1	9/22/2017	NEW	$310,919
														Subtotal = $310,919

Grand Total All Awards = $1,967,674

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Fostering Scientific and Workforce Development by Maintaining and Enriching the CHAMACOS Birth Cohort

Award Number: R24ES028529

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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