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The Michigan PBB Cohort: A unique, highly exposed community followed for 50 years and three generations

Award Number: R24ES028528
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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The Michigan PBB Cohort: A unique, highly exposed community followed for 50 years and three generations - In 1973, millions of Michigan residents were exposed to polybrominated biphenyls (PBB), a flame-retardant chemical, in what is considered one of the largest environmental disasters in US history and led to the creation of the Michigan PBB Registry. At 50 years old, this environmental epidemiology cohort (EEC) is one of the longest running multigenerational cohorts in the US with over 7,500 participants, making it uniquely situated for studying the health effects of an endocrine disrupting chemical (EDC) across the lifecourse and across generations. Since 2011, the Michigan PBB EEC has had strong community-researcher partnerships with the Pine River Superfund Citizen Task Force, PBB Citizen Advisory Board, and Mid-Michigan District Health Department. The Michigan PBB EEC primarily consists of people who were exposed to PBB as adults. In this proposal, we seek to expand community engagement and participation in the PBB EEC to include younger generations through community meetings and focus groups. The expanded cohort will facilitate future research on the generational impacts of EDCs, including biological mechanisms. To date, the Michigan PBB EEC has produced >150 scientific contributions with continuous federal research funding since 1996. We now propose to expand collaboration with participants and scholars from the region where the PBB contamination occurred. We will ensure that this valuable cohort is accessible to trainees and researchers beyond Emory University. We will update the participants’ health status and link PBB EEC data to several cancer registries. We will enhance the Researcher and Participant Portals, improving communication, documentation and metadata, harmonizing standard language and common data elements for optimal data sharing, building family pedigrees to enable generational research, and disseminating our continuing medical education course on EDCs to healthcare providers. The Michigan PBB EEC has trained students since 1996, training 12 postdoctoral fellows and 89 graduate and undergraduate students at multiple colleges and universities. To increase the number of researchers who work with the Michigan PBB EEC, we will promote the Researcher Portal at scientific conferences. Overall, this infrastructure grant will allow the Michigan PBB EEC to continue to expand not only its participants, but trainees and researchers who can learn and generate new scientific knowledge from this unique cohort.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $366,591 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	8	4/29/2026	NON-COMPETING CONTINUATION	$366,591
														Subtotal = $366,591

Issue Date FY: 2024 ( Subtotal = -$66,084 )
2024	2022	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	001	5	9/23/2024	NON-COMPETING CONTINUATION	-$66,084
2024	2022	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	5	3/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = -$66,084

Issue Date FY: 2022 ( Subtotal = $345,631 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	5	7/13/2022	NON-COMPETING CONTINUATION	$345,631
														Subtotal = $345,631

Issue Date FY: 2021 ( Subtotal = $355,133 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	4	7/1/2021	NON-COMPETING CONTINUATION	$355,133
														Subtotal = $355,133

Issue Date FY: 2020 ( Subtotal = $361,986 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	3	7/2/2020	NON-COMPETING CONTINUATION	$361,986
														Subtotal = $361,986

Issue Date FY: 2019 ( Subtotal = $367,655 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	2	6/24/2019	NON-COMPETING CONTINUATION	$367,655
														Subtotal = $367,655

Issue Date FY: 2018 ( Subtotal = $380,502 )
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	1	9/12/2018	NEW	$380,502
														Subtotal = $380,502

Grand Total All Awards = $2,111,414

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The Michigan PBB Cohort: A unique, highly exposed community followed for 50 years and three generations

Award Number: R24ES028528

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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