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Enriching the Rhode Island Child Health Study

Award Number: R24ES028507
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 10/31/2027

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Enriching the Rhode Island Child Health Study - Our overarching goal is to sustain, enrich and enlarge resource infrastructure for the Rhode Island Children’s Health Study (RICHS; Marsit, Stroud MPI: R24ES028507) by facilitating future longitudinal follow up, accelerating data management and sharing, and providing new opportunities for training the scientific workforce. RICHS was developed to characterize the impact of the environment on newborn and early childhood health outcomes with a novel and unique focus on the mechanistic role of placenta molecular function in mediating the impact of the chemical, physical, social, and behavioral environment on infant/child health and disease. The cohort is comprised of 840 mother-infant pairs from the Rhode Island and Southeastern Massachusetts region enrolled using a population-based recruitment strategy. RICHS offspring at the start of this project range in age from 8.8-13.8 years—a critical period for environmental influences on development. Data and results from the cohort have made seminal contributions to elucidating (a) the fundamental molecular biology of the placenta, (b) the impact of environmental exposures on placental epigenetic and genomic regulation, (c) links between placental molecular variation and newborn growth and neurobehavioral outcomes, as well as (d) novel methods development. Resources/investigators from the RICHS cohort contributed to 75 publications (42 during the R24 period), 10 NIH grants including fellowship and career development awards for early career scientists, and >20 post/doctoral projects. The proposed renewal infrastructure support will facilitate prospective, longitudinal assessments of novel child health and disease outcomes, postnatal environmental exposures, (psycho)social determinants of health, as well as continued collection of biospecimens into the RICHS biorepository. The project will also support enrichment of data management and broad sharing of cohort resources, with all activities aimed at providing opportunities for scientists across career stages to access to data and biospecimens to develop novel research questions. Specifically, the goals of this R24 infrastructure support project are to (1) support the infrastructure of of the cohort, (2) continue to obtain longitudinal data on mother-child pairs, (3) expand the RICHS cohort by facilitating enrollment of new participants from complementary Rhode Island cohorts, (4) refine and expand systems for broad sharing of cohort data and resources, (5) increase opportunities for early career scholars to engage with the RICHS cohort, and (6) work with the consortium in developing integrated measures and common strategies for data sharing and collaboration. Ultimately, U24 infrastructure support will maximize NIEHS investment by growing and maintaining the cohort, and adding measures in this highly unique and productive cohort, accelerating discovery and catalyzing future transformative contributions to children’s environmental health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $494,162 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	9	2/13/2026	NON-COMPETING CONTINUATION	$494,162
														Subtotal = $494,162

Issue Date FY: 2024 ( Subtotal = -$343,657 )
2024	2021	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	001	5	11/7/2023	NON-COMPETING CONTINUATION	-$338,077
2024	2020	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	4	11/7/2023	NON-COMPETING CONTINUATION	-$5,580
														Subtotal = -$343,657

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	5	12/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $338,077 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	5	7/2/2021	NON-COMPETING CONTINUATION	$338,077
														Subtotal = $338,077

Issue Date FY: 2020 ( Subtotal = $345,827 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	4	6/23/2020	NON-COMPETING CONTINUATION	$345,827
														Subtotal = $345,827

Issue Date FY: 2019 ( Subtotal = $349,941 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	3	6/25/2019	NON-COMPETING CONTINUATION	$349,941
														Subtotal = $349,941

Issue Date FY: 2018 ( Subtotal = $358,241 )
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	2	7/13/2018	NON-COMPETING CONTINUATION	$358,241
														Subtotal = $358,241

Issue Date FY: 2017 ( Subtotal = $380,859 )
2017	2017	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Environmental Health	000	1	9/22/2017	NEW	$380,859
														Subtotal = $380,859

Grand Total All Awards = $1,923,450

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Enriching the Rhode Island Child Health Study

Award Number: R24ES028507

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 10/31/2027

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