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CFAR Network of Integrated Clinical Systems (CNICS)

Award Number: R24AI067039
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2006
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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CFAR Network of Integrated Clinical Systems (CNICS) - PROJECT SUMMARY / ABSTRACT Modern antiretroviral treatments alter the progression of disease, enabling the majority of HIV+ individuals to live near-normal life spans. Yet, ~ 20% of patients in the US fail to achieve long-term virologic suppression, and even for those who do, there remains the threat of multiple comorbid complications. The critical questions that arise are how will clinicians maximize treatment success, assess the sociobehavioral barriers to linkage and persistent engagement in care, understand the causes of treatment and non-treatment related complications of HIV disease, and develop interventions that maximize health and well-being of HIV infected persons over many decades of life. To address these questions, investigators need access to clinical outcomes information that is tightly linked to biologic specimens and socio-biologic and genetic data to enable translational research. The CFAR Network of Integrated Clinical Systems (CNICS) project is an established resource that has contributed substantially to the contemporary HIV research agenda. Established in 2002 and funded as an R24 research platform in 2006, CNICS is a clinic-based research network that reflects the outcomes of clinical decisions and management options used in the care of HIV infected individuals at 8 CFAR sites: UAB, U Washington, UCSF, UCSD, Case Western Reserve, Fenway Health (Brown / Harvard), U North Carolina, and Johns Hopkins. What makes CNICS unique is the way in which CNICS augments the comprehensive EHR data with a combination of other resources for research that include patient-reported and patient-centered socio-behavioral data; adjudication of key clinical events; strategic biological specimen collection; and genetic characterization of the cohort. The mission of CNICS is to provide access to the specimen and data repository to any investigator who submits an approved concept proposal. In this fashion, CNICS is a 'peer-reviewed open access' research platform available to investigators worldwide. The specific aims for this competitive renewal of CNICS leverages the robust CNICS foundation to accomplish the following: 1: Collect high quality data from a representative sample of patients; 2: Enable investigators to perform research by providing data and specimens to a diverse array of scientists worldwide; and 3: Mentor early to mid-career investigators engaged in HIV-focused research in CNICS.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $6,404,188 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	19	8/8/2024	NON-COMPETING CONTINUATION	$6,404,188
														Subtotal = $6,404,188

Issue Date FY: 2023 ( Subtotal = $6,379,535 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	18	8/21/2023	NON-COMPETING CONTINUATION	$6,409,312
2023	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	15	2/9/2023	SUPPLEMENT FOR EXPANSION	-$29,777
2023	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	15	11/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,379,535

Issue Date FY: 2022 ( Subtotal = $6,416,904 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	17	8/22/2022	NON-COMPETING CONTINUATION	$6,416,904
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	16	4/12/2022	COMPETING CONTINUATION	$1,672,135
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	15	4/12/2022	NON-COMPETING CONTINUATION	-$1,672,135
														Subtotal = $6,416,904

Issue Date FY: 2021 ( Subtotal = $6,779,419 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	16	7/8/2021	COMPETING CONTINUATION	$6,592,862
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	15	1/6/2021	SUPPLEMENT FOR EXPANSION	$186,557
														Subtotal = $6,779,419

Issue Date FY: 2020 ( Subtotal = $4,456,708 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	15	7/31/2020	NON-COMPETING CONTINUATION	$4,456,708
														Subtotal = $4,456,708

Issue Date FY: 2019 ( Subtotal = $4,841,410 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	003	14	9/5/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	14	8/15/2019	NON-COMPETING CONTINUATION	$4,648,045
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	14	9/3/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	14	8/30/2019	SUPPLEMENT FOR EXPANSION	$193,365
														Subtotal = $4,841,410

Issue Date FY: 2018 ( Subtotal = $4,462,005 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	13	8/9/2018	NON-COMPETING CONTINUATION	$4,462,005
2018	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	11	8/20/2018	COMPETING CONTINUATION	$19,882
2018	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	10	8/20/2018	NON-COMPETING CONTINUATION	-$19,882
														Subtotal = $4,462,005

Issue Date FY: 2017 ( Subtotal = $4,449,941 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	003	12	8/10/2017	NON-COMPETING CONTINUATION	$4,449,941
2017	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	11	3/8/2017	COMPETING CONTINUATION	$359,539
2017	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	11	3/9/2017	COMPETING CONTINUATION	$0
2017	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	10	3/8/2017	NON-COMPETING CONTINUATION	-$359,539
														Subtotal = $4,449,941

Issue Date FY: 2016 ( Subtotal = $4,515,387 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	11	5/6/2016	COMPETING CONTINUATION	$4,515,387
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	352940111	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	11	6/1/2016	COMPETING CONTINUATION	$0
														Subtotal = $4,515,387

Issue Date FY: 2015 ( Subtotal = $3,597,088 )
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	10	8/5/2015	NON-COMPETING CONTINUATION	$3,597,088
														Subtotal = $3,597,088

Issue Date FY: 2014 ( Subtotal = $4,039,225 )
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	9	8/7/2014	NON-COMPETING CONTINUATION	$499,715
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	9	7/30/2014	NON-COMPETING CONTINUATION	$3,539,510
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	9	8/12/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,039,225

Issue Date FY: 2013 ( Subtotal = $3,274,075 )
2013	2013	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	8	8/20/2013	NON-COMPETING CONTINUATION	$3,274,075
														Subtotal = $3,274,075

Issue Date FY: 2012 ( Subtotal = $4,366,443 )
2012	2012	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	7	9/26/2012	NON-COMPETING CONTINUATION	$0
2012	2012	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	7	8/9/2012	NON-COMPETING CONTINUATION	$3,427,717
2012	2012	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	7	9/25/2012	NON-COMPETING CONTINUATION	$938,726
														Subtotal = $4,366,443

Issue Date FY: 2011 ( Subtotal = $3,524,697 )
2011	2011	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	6	8/4/2011	COMPETING CONTINUATION	$3,513,072
2011	2010	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Recovery Act Research Support	000	5	1/21/2011	SUPPLEMENT FOR EXPANSION	$11,625
2011	2009	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Recovery Act Research Support	002	4	8/29/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,524,697

Issue Date FY: 2010 ( Subtotal = $3,296,487 ) (Continued on the next page)
2010	2010	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	004	5	8/22/2010	NON-COMPETING CONTINUATION	$3,088,600
Grand Total All Awards = $84,568,882

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CFAR Network of Integrated Clinical Systems (CNICS)

Award Number: R24AI067039

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2006

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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