Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Zambian Cohort of Healthy Aging and Dementia (ZCHAD) Study

Award Number: R21TW013270
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2026
PERIOD OF PERFORMANCE END DATE: 02/29/2028

Group Awards By:

View Award Description

Zambian Cohort of Healthy Aging and Dementia (ZCHAD) Study - Project Abstract Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) affect 51 million people worldwide, a prevalence expected to triple by 2050. Two-thirds of those with AD/ADRD live in low- and middle- income countries (LMICs) where the greatest growth in AD/ADRD prevalence is expected, but where services to diagnose and manage this condition are scarce and data regarding dementia burden are limited. Although the Lancet Commission on Dementia, Prevention, Intervention, and Care has identified 14 modifiable risk factors that contribute to 45% of AD/ADRD cases worldwide, there are limited data regarding the prevalence and role of these modifiable risk factors in LMICs. Thus, interventions targeting these factors may have limited impact on AD/ADRD risk in LMIC settings. This proposal’s overall objective is to assess the prevalence rate of AD/ADRD and associated risk factors among adults age ≥55 years in urban and rural Zambia, a LMIC in sub- Saharan Africa. Based on our pilot work, we hypothesize that the prevalence rate of AD/ADRD among adults age ≥55 years will be approximately 9.5% and prevalence of associated risk factors will differ between urban and rural participants. These hypotheses will be tested through a population-based study of adults age ≥55 years in the urban Lusaka and rural Mazabuka Districts of Zambia. AD/ADRD prevalence will be assessed using formal neuropsychological testing, participant, and informant report according to DSM-V criteria. Additional validated questionnaires, a physical examination, and laboratory investigations will assess AD/ADRD risk factors. This project will also build and expand the neuropsychiatric expertise and workforce necessary to conduct prospective AD/ADRD research by providing training and AD/ADRD research experience for a Zambian neuropsychologist, neuropsychologists-in-training, and a cohort of community health workers. The proposed research is highly innovative because it examines AD/ADRD prevalence in a population with limited existing data and expected growth in rates of AD/ADRD and associated risk factors. Knowledge gained from this work will determine (1) the prevalence of AD/ADRD and (2) the prevalence of modifiable risk factors which have the greatest impact on AD/ADRD prevalence in this rapidly aging population. This project will have a significant impact by expanding the capacity for AD/ADRD studies in Zambia and will lay the groundwork for the conduct of future longitudinal studies and trials assessing low-cost interventions to reduce AD/ADRD prevalence and improve patient care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $176,583 )
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	International Research and Research Training	000	1	2/25/2026	NEW	$99,747
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	International Research and Research Training	001	1	2/27/2026	SUPPLEMENT FOR EXPANSION	$76,836
														Subtotal = $176,583

Grand Total All Awards = $176,583

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Zambian Cohort of Healthy Aging and Dementia (ZCHAD) Study

Award Number: R21TW013270

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2026

PERIOD OF PERFORMANCE END DATE: 02/29/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer