Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Persistent Vascular Dysfunction and Cognition among Virally Suppressed People with HIV

Award Number: R21TW012880
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2027

Group Awards By:

View Award Description

Persistent Vascular Dysfunction and Cognition among Virally Suppressed People with HIV - Modified Project Summary/Abstract Section With antiretroviral therapy (ART), many people with HIV (PWH) now achieve durable viral suppression and survive into older age. However, persistent immune activation and vascular dysfunction remain common and may contribute to cognitive impairment despite viral suppression. This project will evaluate whether vascular dysfunction is linked to cognitive performance in virally suppressed older PWH by integrating plasma biomarkers, optical coherence tomography angiography (OCTA) as a non-invasive retinal microvascular measure, and comprehensive cognitive assessment. We will enroll 250 participants aged ≥50 years (200 PWH on stable ART and 50 people without HIV matched on age and biological sex) in Bangkok, Thailand, leveraging the HIV Netherlands Australia Thailand Research Collaboration (HIVNAT) infrastructure and its well-characterized longitudinal cohort. The study will: (1) compare immune activation and vascular/endothelial dysfunction biomarkers and OCTA metrics between PWH and controls; and (2) compare cognitive performance between groups and test associations among cognition, OCTA measures, and biomarker-derived subgroups. Foreign component justification: The work is conducted at HIVNAT of Thai Red Cross AIDS Research Centre and Chulalongkorn University because it provides a unique, well-followed cohort of virally suppressed older PWH with long-term ART exposure, established research laboratory capacity, and on-site access to OCTA facilities within the clinical care network. These resources and the underlying HIV subtype (CRF01_AE), genetic, and environmental context are not readily replicated within a single U.S. cohort and provide a complementary scientific opportunity to test generalizable vascular–cognitive mechanisms. Benefit to American health: The mechanisms evaluated, endothelial dysfunction, immune activation, microvascular injury, and their relationship to cognitive performance, are directly relevant to the growing U.S. population of older PWH on ART. Results will inform risk stratification and early identification strategies (including evaluation of OCTA as a scalable screening approach) and will guide future implementation studies to mitigate vascular contributions to cognitive impairment in Americans living with HIV.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $148,401 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	International Research and Research Training	002	2	7/14/2026	NON-COMPETING CONTINUATION	$0
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	International Research and Research Training	001	2	7/6/2026	SUPPLEMENT FOR EXPANSION	$78,607
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	International Research and Research Training	000	2	6/23/2026	NON-COMPETING CONTINUATION	$69,794
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	International Research and Research Training	003	2	7/15/2026	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $148,401

Issue Date FY: 2025 ( Subtotal = $220,518 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	International Research and Research Training	000	1	9/7/2025	NEW	$103,474
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	International Research and Research Training	001	1	9/14/2025	SUPPLEMENT FOR EXPANSION	$117,044
														Subtotal = $220,518

Grand Total All Awards = $368,919

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Persistent Vascular Dysfunction and Cognition among Virally Suppressed People with HIV

Award Number: R21TW012880

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer