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Subclinical cardiac dysfunction after hypertensive disorders in pregnancy

Award Number: R21TW011460
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/06/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Subclinical cardiac dysfunction after hypertensive disorders in pregnancy - 7. ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality globally. About three quarters of CVD deaths occur in the low- and middle-income settings. Although CVD related deaths have progressively declined in high income settings, mortality among adults below 55 years especially women have stagnated, most likely due to female specific risk factors. One such factor, new onset hypertensive disorders of pregnancy (HDP) is associated with 2-fold or greater risk for future metabolic syndrome, chronic low-grade inflammation and heart failure. However, majority of studies on long-term heart failure risk after HDP have mostly focused on end-stage disease and not the progression of asymptomatic cardiac dysfunction. Previous studies have shown that even the asymptomatic patients with myocardial dysfunction have compromised prognosis with an increased risk of developing symptomatic heart failure in the future. Therefore, early identification of at-risk population of women is critical and would allow implementation of intervention strategies to delay the progression or to prevent the onset of heart failure. Few studies in high income settings and none in SSA have evaluated the risk and correlates of subclinical cardiac dysfunction after HDP using speckle tracking echocardiography (STE) which accurately quantifies myocardial mechanics, including global longitudinal strain (GLS), a prognostic marker of adverse CVD outcomes. Using STE, we aim to understand and describe the presence and progression of asymptomatic cardiac dysfunction after pregnancies complicated with HDP (Aim 1) and evaluate the contribution of inflammation at 3 years postpartum by comparing women with and without new onset of new hypertensive disorders of pregnancy (Aims 2 and 3). The study findings will inform the development of novel and scalable screening and monitoring strategies to manage CVD risk after HDP and therefore reduce CVD and CVD- mortality in sub-Saharan Africa and globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	UNIVERSITY OF NAIROBI	UNIVERSITY WAY IN NAIROBI CENTRAL BUSINESS DISTRICT.	NAIROBI				KEN	International Research and Research Training	000	2	3/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	UNIVERSITY OF NAIROBI	UNIVERSITY WAY	NAIROBI	NULL			KEN	International Research and Research Training	000	2	5/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $140,581 )
2020	2020	UNIVERSITY OF NAIROBI	UNIVERSITY WAY	NAIROBI				KEN	International Research and Research Training	000	2	4/23/2020	NON-COMPETING CONTINUATION	$140,581
														Subtotal = $140,581

Issue Date FY: 2019 ( Subtotal = $187,016 )
2019	2019	UNIVERSITY OF NAIROBI	UNIVERSITY WAY	NAIROBI				KEN	International Research and Research Training	000	1	8/25/2019	NEW	$187,016
														Subtotal = $187,016

Grand Total All Awards = $327,597

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Subclinical cardiac dysfunction after hypertensive disorders in pregnancy

Award Number: R21TW011460

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/06/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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