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A HIGH-THROUGHPUT FLOW SYSTEM TO PROBE BIOMECHANICS OF PATHOPHYSIOLOGY

Award Number: R21RR031253
ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2010
PERIOD OF PERFORMANCE END DATE: 04/30/2013

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A HIGH-THROUGHPUT FLOW SYSTEM TO PROBE BIOMECHANICS OF PATHOPHYSIOLOGY - DESCRIPTION (provided by applicant): A High-Throughput Flow System to Probe Biomechanics of Pathophysiology Recent advances in cell culture modalities and high-throughput screening technology have vastly expanded our potential for biological discovery, and have opened the door toward therapeutic advances in the development of new compounds and cell-based therapies for treatment of a wide range of diseases. Nevertheless, current systems do not have the capability to probe cellular function in the context of the complex biomechanical environments that dictate the fate and functional phenotype of multiple cell types comprising diverse tissue milieus in vivo. Here we propose to develop and implement a dynamic high-throughput flow system that delivers programmable, time- varying fluid dynamic waveforms to cultured cells grown in individual wells of a commercially available 96-well plate. This platform should allow the systematic investigation of signaling pathways in biological systems whose function and dysfunction critically depends on the fluid mechanical environment. Development of this instrument will enable better understanding of human pathophysiology and lead to the discovery of new therapeutic targets or modalities for clinical interventions for a broad range of diseases and clinical and research applications. PUBLIC HEALTH RELEVANCE: Narrative A High-Throughput Flow System to Probe Biomechanics of Pathophysiology This project aims to develop, for the first time, a high-throughput instrument capable of culturing cells in a conventional 96-well plate and applying precise mechanical forces to them. This capability will enable new and more efficient methods to investigate cardiovascular diseases, blood disorders, cancer and other conditions using more realistic laboratory models, and will accelerate the development of safer and more efficacious therapeutic treatments for these diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $216,818 )
2011	2011	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	National Center for Research Resources	001	2	9/1/2011	NON-COMPETING CONTINUATION	$1,398
2011	2011	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	National Center for Research Resources	000	2	5/6/2011	NON-COMPETING CONTINUATION	$215,420
														Subtotal = $216,818

Issue Date FY: 2010 ( Subtotal = $219,008 )
2010	2010	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	National Center for Research Resources	000	1	7/27/2010	NEW	$219,008
														Subtotal = $219,008

Grand Total All Awards = $435,826

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A HIGH-THROUGHPUT FLOW SYSTEM TO PROBE BIOMECHANICS OF PATHOPHYSIOLOGY

Award Number: R21RR031253

ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2010

PERIOD OF PERFORMANCE END DATE: 04/30/2013

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