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UPTAKE AND PROCESSING OF FOREIGN DNA BY MITOCHONDRIA, A MODEL SYSTEM

Award Number: R21RR023368
ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2007
PERIOD OF PERFORMANCE END DATE: 06/30/2011

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UPTAKE AND PROCESSING OF FOREIGN DNA BY MITOCHONDRIA, A MODEL SYSTEM - DESCRIPTION (provided by applicant): The mechanisms by which foreign DNAs enter mitochondria are largely unknown. The goal of the proposed studies is to develop an in vitro model for study of uptake, replication and transcription of foreign DNA by mitochondria. This cell culture based model system will take advantage of a unique virus-like agent which infects and replicates in the mitochondria of tumor cells in a tropical marine fish, the bicolor damselfish (Stegastes partitus). This transmissible agent (DVLA) is associated with the naturally occurring, infectious disease termed damselfish neurofibromatosis. DVLA does not resemble any known family of virus or viroid. The unusual sequence and secondary structure of the DNA genome of this agent are likely a direct result of the apparently unique life-style of this agent and may provide clues to optimizing uptake and processing of foreign DNA by mitochondria. The aims of the proposed study are to examine the entry of DVLA DNA into isolated mitochondria and evaluate the replication and transcription of this DNA in the mitochondria. This is a high risk research project with the potential to yield data which should be widely applicable to understanding pathogenesis in mitochondria and for development of techniques for mitochondrial transgenesis in other vertebrates.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2008	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	National Center for Research Resources	000	2	6/10/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $188,038 )
2008	2008	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	National Center for Research Resources	000	2	5/23/2008	NON-COMPETING CONTINUATION	$188,038
														Subtotal = $188,038

Issue Date FY: 2007 ( Subtotal = $191,875 )
2007	2007	UNIVERSITY OF MIAMI	POST OFFICE BOX 248106	CORAL GABLES	FL	33124	MIAMI-DADE	USA	National Center for Research Resources	000	1	6/22/2007	NEW	$191,875
														Subtotal = $191,875

Grand Total All Awards = $379,913

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UPTAKE AND PROCESSING OF FOREIGN DNA BY MITOCHONDRIA, A MODEL SYSTEM

Award Number: R21RR023368

ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2007

PERIOD OF PERFORMANCE END DATE: 06/30/2011

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