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Development of foundational building blocks for stable genetic modification of sea urchin embryos

Award Number: R21OD034075
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2022
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Development of foundational building blocks for stable genetic modification of sea urchin embryos - PROJECT SUMMARY Animal models are essential for understanding the mechanisms of development, and for uncovering the early life origins of disease. The utility of these models depends on the effective application of genetic methods to establish causal relationships between genes and phenotypes. The goal of this proposal, targeted to the Office of Research Infrastructure Programs (ORIP), is to build resources that dramatically improve the reproducibility, utility, and efficiency of research in sea urchins - which are used by hundreds of researchers across numerous NIH-supported projects. These resources include modular founder lines (“building blocks”) enabling myriad approaches, from cell and stage-specific mutagenesis to combinatorial fluorescent reporter expression, to active genetics. The Aims of this proposal utilize both traditional (transposon- mediated transgenesis) and modern (CRISPR/Cas9) techniques to meet these diverse needs. Further innovation of the work comes from application of this modular genetic design to a species with the ideal biological features and background of knowledge for transgenesis and research- scale culturing. This work will have transformative impact on research across the mandates of NIH, including studies on reproduction, membrane transport, and gene regulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Research Infrastructure Programs	000	2	4/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $197,500 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Research Infrastructure Programs	001	2	5/8/2024	NON-COMPETING CONTINUATION	$39,500
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Research Infrastructure Programs	000	2	11/29/2023	NON-COMPETING CONTINUATION	$158,000
														Subtotal = $197,500

Issue Date FY: 2023 ( Subtotal = $237,000 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Research Infrastructure Programs	001	1	3/6/2023	NEW	$23,700
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Research Infrastructure Programs	000	1	12/9/2022	NEW	$213,300
														Subtotal = $237,000

Grand Total All Awards = $434,500

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Development of foundational building blocks for stable genetic modification of sea urchin embryos

Award Number: R21OD034075

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2022

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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