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Molecular cartography of initiating and infiltrating glioma cells using multisector sampling and spatial transcriptomics

Award Number: R21NS142788
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Molecular cartography of initiating and infiltrating glioma cells using multisector sampling and spatial transcriptomics - SUMMARY Diffuse dissemination of tumor cells into the brain is one of the key problems impacting optimal treatment of gliomas. We hypothesize that distinct types of tumor cells harbor characteristic diffusion patterns. Specifically, we suspect that NPC-like cells predominate in the cortical layers and interact with the laminar extension of neuronal cells in the cortex, while OPC-like cells dominate subcortically and associate with axons and APC-like cells associate with vascular and immune cells. In order to provide four-dimensional reconstructions of tumor development and test our hypotheses, we will perform spatial transcriptomics on n = 254 image-mapped samples from n = 22 distinct tumors (aim 1). Tumor-microenvironment interactions will be evaluated separately for each patient and by comparing distinct locations across patients. Finally, we will develop an agent-based model using n = 179 samples from n = 20 individual with integrated imaging, DNA methylation and DNA sequencing information to reconstruct historical and forecast future tumor development in space and time (aim 2). The findings of these studies will allow for a high-resolution dissection of the identity and location of ancestral stem- like tumor cell populations, as well as the identification of sites of diffuse infiltration. A four-dimensional model of tumor cell dissemination will enable individualized local treatment planning and prognostication.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $305,960 )
2026	2026	TRANSLATIONAL GENOMICS RESEARCH INSTITUTE	445 N 5TH ST	PHOENIX	AZ	85004	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/13/2026	NEW	$305,960
														Subtotal = $305,960

Grand Total All Awards = $305,960

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Molecular cartography of initiating and infiltrating glioma cells using multisector sampling and spatial transcriptomics

Award Number: R21NS142788

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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