Thursday, July 3, 2025 7/3/2025

Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds

Award Number: R21NS137054
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2026

Group Awards By:

View Award Description

Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds - PROJECT SUMMARY Neuropathic pain is a pervasive and debilitating condition associated with modifications in synaptic plasticity and altered gene expression within the spinal cord. However, the specific molecular mechanisms underlying these synaptic changes remain poorly understood. This proposed project aims to unravel the synaptic transcriptome modifications occurring during neuropathic pain and investigate the involvement of G- quadruplexes in translocation of transcripts at the synapse. The outcomes of this study will provide a comprehensive map of the synaptic transcriptomic changes in neuropathic pain and elucidate some of the factors contributing to this alteration. Furthermore, it will pave the way for the development of innovative therapeutic strategies targeting the G-quadruplexes, ultimately offering new avenues for the management of neuropathic pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $227,250 )
2025	2025	SAINT LOUIS UNIVERSITY	221 N GRAND BLVD	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/14/2025	NON-COMPETING CONTINUATION	$227,250
														Subtotal = $227,250

Issue Date FY: 2024 ( Subtotal = $189,375 )
2024	2024	SAINT LOUIS UNIVERSITY	221 N GRAND BLVD	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/11/2024	NEW	$189,375
														Subtotal = $189,375

Grand Total All Awards = $416,625

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds

Award Number: R21NS137054

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer