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Biophysical Studies of Non-Invasive Brain Cell Stimulation with Focused Ultrasound

Award Number: R21NS101384
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2017
PERIOD OF PERFORMANCE END DATE: 09/29/2020

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Biophysical Studies of Non-Invasive Brain Cell Stimulation with Focused Ultrasound - Abstract Low-intensity pulsed ultrasound stimulation (LIPUS) is a promising technology for non-invasive deep brain neuromodulation. Unfortunately, this technology is presently not available in the clinic due to the lack of understanding of the molecular and cellular processes that take place in brain cells upon ultrasound stimulation. The goal of this project is to uncover these mechanism(s). Our preliminary data show that LIPUS elicit robust and consistent calcium signals in astrocytes, suggesting a totally unanticipated mechanism wherein the neuromodulatory effects of LIPUS are mediated by astrocytes, via direct or indirect activation of calcium channels. To investigate these hypotheses, we propose to dissect LIPUS-induced calcium signaling in astrocytes and neurons using pharmacological agents. If successful, this work will help make this new technology available to patients who currently do not have access to effective and safe therapeutic options. Non-invasive astrocyte stimulation with ultrasound may also lead to new treatments for traumatic brain injury, neurovascular diseases or dementia. In parallel to this effort, we will develop genetically-encoded fluorescent reporters of mechanical deformations of plasma membranes induced upon LIPUS. Our preliminary molecular engineering design is very promising and will lead to a patent application upon further characterization and optimization. These sensors will enable rapid and easy localization and quantification of physical perturbations produced in cells and tissues by exogenous and endogenous mechanical forces. We expect these reporters to have a major impact in mechanobiology and nanotechnology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$5,161 )
2021	2018	WESTERN UNIVERSITY OF HEALTH SCIENCES	309 E 2ND ST	POMONA	CA	91766	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/15/2021	NON-COMPETING CONTINUATION	-$5,161
														Subtotal = -$5,161

Issue Date FY: 2018 ( Subtotal = $209,450 )
2018	2018	WESTERN UNIVERSITY OF HEALTH SCIENCES	309 E 2ND ST	POMONA	CA	91766	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/13/2018	NON-COMPETING CONTINUATION	$209,450
														Subtotal = $209,450

Issue Date FY: 2017 ( Subtotal = $175,840 )
2017	2017	WESTERN UNIVERSITY OF HEALTH SCIENCES	309 E 2ND ST	POMONA	CA	91766	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2017	NEW	$175,840
														Subtotal = $175,840

Grand Total All Awards = $380,129

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Biophysical Studies of Non-Invasive Brain Cell Stimulation with Focused Ultrasound

Award Number: R21NS101384

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2017

PERIOD OF PERFORMANCE END DATE: 09/29/2020

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