Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

IN-VIVO RAT BRAIN PET STUDY OF TASK SPECIFIC MOTOR RECOVERY AFTER STROKE

Award Number: R21NS074244
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2012
PERIOD OF PERFORMANCE END DATE: 06/30/2014

Group Awards By:

View Award Description

IN-VIVO RAT BRAIN PET STUDY OF TASK SPECIFIC MOTOR RECOVERY AFTER STROKE - DESCRIPTION (provided by applicant): Stroke is the leading cause of severe long-term disability in adults in the United States. Unfortunately, there are no clinical approaches proven to promote functional improvement once stroke has occurred. Recent studies using animal stroke models have demonstrated that treatment with an anti-Nogo-A antibody (Ab) improved motor functional recovery and enhanced the adult brain to "rewire", i.e. enhanced Neuroplasticity. Further understanding of the dynamics underlying such improvement and brain reorganization is in great need. In this study we propose to use the small-animal micro positron emission tomography (5PET) and micro computed tomography (5CT) to provide in vivo 3-dimensional (3D) imaging and investigate the correlations between brain activity, functional improvement, and neuroanatomical plasticity in the rat following stroke and anti-Nogo-A Ab treatment. In vivo 3D PET imaging provides the opportunity of direct observation of the correlations between the responses of a biological system in response to treatment, challenge, and manipulations. It also enables longitudinal studies and significantly improves data quality by eliminating inter-animal variability while providing increased observation points. Since animals will not be sacrificed at regular intervals for histological analysis, the total number of animals needed is greatly reduced. In this proposal, we will first develop a novel model using 5PET/5CT imaging to detect brain activity of rats corresponding to a specific motor activity, the skilled forelimb reaching task. We will further combine this in vivo 5PET/5CT imaging method with our well-established and reproducible model for stroke, and recovery, and neuroplasticity. We will use this novel approach to examine whether 5PET/5CT imaging can detect changes in motor activity of the unlesioned hemisphere corresponding to the functional recovery after stroke and anti-Nogo-A Ab treatment in adult rats. Results derived from this proposed study will provide in depth information of understanding brain activity in areas such as the sensorimotor cortex and striatum, during the progression of motor functional improvement and corresponding brain reorganization after stroke and anti-Nogo-A Ab treatment. Such information will be of great value in future development of new approaches to enhance functional improvement, and benefit patients suffering from the sequelae after stroke.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $200,437 )
2013	2013	CHICAGO ASSOCIATION FOR RESEARCH & ED IN SCIENCE	BLDG ONE RM C307PO BOX 250	HINES	IL	60141	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/26/2013	NON-COMPETING CONTINUATION	$200,437
														Subtotal = $200,437

Issue Date FY: 2012 ( Subtotal = $175,222 )
2012	2012	CHICAGO ASSOCIATION FOR RESEARCH & ED IN SCIENCE	BLDG ONE RM C307PO BOX 250	HINES	IL	60141	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/22/2012	NEW	$175,222
														Subtotal = $175,222

Grand Total All Awards = $375,659

Top

All Categories

About

Search

Reports

Data Submission

Award Information

IN-VIVO RAT BRAIN PET STUDY OF TASK SPECIFIC MOTOR RECOVERY AFTER STROKE

Award Number: R21NS074244

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2012

PERIOD OF PERFORMANCE END DATE: 06/30/2014

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer