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A FLUORESCENCE POLARIZATION ASSAY FOR METHYLTRANSFERASES

Award Number: R21NS053726
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2005
PERIOD OF PERFORMANCE END DATE: 08/31/2006

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A FLUORESCENCE POLARIZATION ASSAY FOR METHYLTRANSFERASES - DESCRIPTION (provided by applicant): Methylation is vital in many biological processes, and potent and specific inhibitors of methyltransferases are valuable tools in understanding these processes. Some positive clinical and preclinical results from DMA methyltransferase inhibitors indicate the potential use of these inhibitors in cancer therapy. In this proposal, we intend to develop a fluorescence polarization assay which is non-radioactive and amenable to high throughput screening. This will greatly facilitate the discovery of novel inhibitors of methyltransferases by high throughput screening. These inhibitors will be not only valuable research tools to study the large family of important enzymes but also initial leads to develop future drugs for cancer and other diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $180,000 )
2005	2005	UNIVERSITY OF KANSAS	2385 IRVING HILL ROAD	LAWRENCE	KS	66044	DOUGLAS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/23/2005	NEW	$180,000
														Subtotal = $180,000

Grand Total All Awards = $180,000

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A FLUORESCENCE POLARIZATION ASSAY FOR METHYLTRANSFERASES

Award Number: R21NS053726

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2005

PERIOD OF PERFORMANCE END DATE: 08/31/2006

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