Friday, April 26, 2024 4/26/2024

Noninvasive Adherence-independent Longitudinal Remote Chronic Disease Monitoring and Exacerbation Inference

Award Number: R21NR018558
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Abstract: The 30-day hospital readmission rate in the U.S. exceeds 3 million patients per year with cost estimates exceeding $40B. More than 10% of these hospitalizations are considered preventable. Chronic and recurrent cardiopulmonary diseases (heart failure, pneumonia, COPD, cardiac dysrhythmias, acute myocardial infarction) are among the most common causes of rehospitalization. Heart failure alone affects more than 6 million US patients, is responsible for >1 million hospitalizations annually, and is associated with remarkably high hospital readmission rates (~25% at 30 days; ~50% by 6 months). Intense focus has centered on improving outpatient disease management using remote monitoring during vulnerable periods (immediately after hospital discharge) and in vulnerable underserved populations. Despite its promise, the utility of remote health monitoring has been limited by lack of adherence to patient self-measurement and data transmission. Even implantable devices often require patient-initiated data transmission. We propose a noninvasive and fully adherence-independent in-home monitor of cardiopulmonary clinical biomarkers with fully automated data transmission. By overcoming the compliance barrier, the sensing platform enables reliable longitudinal measurement with potential to infer signatures of impending hospitalizations. The proposed R21 will 1) deploy the technology into the homes of patients discharged after a hospitalization for heart failure exacerbation with volume overload, and 2) perform longitudinal monitoring to generate data that will be used for inference and patient feedback. If successful, this real-world pilot data will inform design of a formal observational trial to infer signatures of chronic disease decompensation and impending need for hospitalization.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Nursing Research	000	2	6/13/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $197,240 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Nursing Research	000	2	3/8/2021	NON-COMPETING CONTINUATION	$197,240
														Subtotal = $197,240

Issue Date FY: 2020 ( Subtotal = $236,250 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Nursing Research	000	1	2/20/2020	NEW	$236,250
														Subtotal = $236,250

Grand Total All Awards = $433,490

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Noninvasive Adherence-independent Longitudinal Remote Chronic Disease Monitoring and Exacerbation Inference

Award Number: R21NR018558

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer