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Predicting maladaptive aversive learning via computational modeling of insular single cell ensemble activity patterns

Award Number: R21MH132052
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Anxiety disorders such as panic disorders, generalized anxiety disorder, and post-traumatic stress disorder (PTSD) affect approximately 18% of the American population with a health care cost of more than $42 billion a year, a significant burden to the US economy. Development and maintenance of anxiety disorders have been attributed to persistent fear memories, inadequate fear extinction, and maladaptive avoidance behavior. Thus, it is imperative to understand the neural mechanisms underlying aversive learning in order to be able to develop efficacious treatments for these disorders. In this project, we will focus on understanding the involvement of the insula, a brain region heavily involved not only in aversive learning in general but also processes determining approach/avoidance behaviors. Specifically, using in-vivo single cell calcium imaging via miniscopes, we will record activity patterns of insular single cell ensembles during fear learning when the aversive outcome (footshock) is inescapable as well as when the aversive outcome is omitted (fear extinction; Aim1a) and when it becomes escapable (avoidance learning; Aim1b). Finally, using a novel theoretical-computational approach to functionally cluster fear learning single cell ensembles in the insula, we will predict whether mice will develop extinction resistant fear or impaired avoidance learning (Aim2). Thus, in this proposal, we aim to investigate the involvement of the insular single cell ensembles in aversive learning and develop a novel computational tool to predict future maladaptive aversive learning phenotypes based on the neural signaling in the insula.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $213,832 )
2024	2024	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Mental Health Research Grants	002	3	3/1/2024	NON-COMPETING CONTINUATION	$214,024
2024	2023	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	1	2/10/2024	NEW	-$182,964
2024	2023	RU SCHOOL OF OSTEOPATHIC MEDICINE	42 E LAUREL RD	STRATFORD	NJ	08084	CAMDEN	USA	Mental Health Research Grants	001	2	2/12/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$182,772
														Subtotal = $213,832

Issue Date FY: 2023 ( Subtotal = $198,125 )
2023	2023	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	1	3/8/2023	NEW	$198,125
														Subtotal = $198,125

Grand Total All Awards = $411,957

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Predicting maladaptive aversive learning via computational modeling of insular single cell ensemble activity patterns

Award Number: R21MH132052

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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