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Real-time visualization and precision targeting in transcranial magnetic stimulation

Award Number: R21MH126396
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Real-time visualization and precision targeting in transcranial magnetic stimulation - Project Summary Title: Real-time visualization and precision targeting in transcranial magnetic stimulation Transcranial magnetic stimulation (TMS) is a non-invasive device-based neuromodulation technique for probing neuronal networks and treating mental disorders such as major depressive disorder (MDD) and Obsessive- Compulsive Disorder (OCD). The treatment efficacy of TMS relies on placing TMS coils to accurately stimulate the underlying disease-related brain target. Since TMS-evoked electric field (E-field) is affected by complex tissue structures and brain geometry, it relies on using computational algorithms, such as boundary element modeling (BEM) and finite element modeling (FEM), to estimate the stimulation site. But the relative long computation time of these methods is a limitation for real-time visualization of the stimulation target during brain mapping and for computing the optimal coil position for treatment planning. In this grant, we propose to develop a deep-neural-network based method to accelerate E-field prediction. We will develop a novel deep-neural- network architecture to predict E-field by using training data computed using the FEM algorithm with anisotropic tissue conductivity. Then, we will integrate the trained neural network into a 3DSlicer software module for real- time E-field visualization. Moreover, we will develop a computational algorithm to search for the optimal coil position to maximize the stimulation of a selected brain target within a clinically feasible time. The outcome of this grant will transform deep-learning techniques into a useful tool to enhance the application of TMS in clinical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$3 )
2025	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	2	6/11/2025	NON-COMPETING CONTINUATION	-$3
														Subtotal = -$3

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	2	2/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $215,722 )
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	2	1/5/2022	NON-COMPETING CONTINUATION	$194,149
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	2	6/26/2022	NON-COMPETING CONTINUATION	$21,573
														Subtotal = $215,722

Issue Date FY: 2021 ( Subtotal = $277,289 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	1	1/15/2021	NEW	$277,289
														Subtotal = $277,289

Grand Total All Awards = $493,008

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Real-time visualization and precision targeting in transcranial magnetic stimulation

Award Number: R21MH126396

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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