Sunday, August 24, 2025 8/24/2025

Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository

Award Number: R21HL140268
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/17/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2023

Group Awards By:

View Award Description

Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository - Abstract Triggering receptor expressed in Myeloid cells (TREM) Like transcript (TLT)-1 is a prominent platelet receptor stored in the -granules of platelets. While it is virtually absent on the surface resting platelets, it highly expressed on the surface of activated platelets and released as a soluble fragment (sTLT-1). TLT-1 binds to neutrophils and endothelial cells. During acute inflammation it mediates smooth leukocyte transmigration out of the vessels protecting the vessels from excessive bleeding. The effect is particularly prominent in the lungs. TLT-1 interaction with endothelial cells initiates cell growth and proliferation and when targeted in a Lewis lung carcinoma model displays anti-angiogenic properties. As such our studies have defined roles for TLT-1 in acute lung inflammation, atherosclerosis, and cancer. Here we propose to clinically translate our findings using the rich resource presented by the NIH biorepository. We will investigate samples from ARDS patients to find clinical correlation of TLT-1 positive microparticles with the mortality and hospital stay. We will evaluate samples from cardiovascular patients in the PEACE study for correlations of the soluble fragment and TLT-1 positive microparticles with adverse cardiac events..


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	000	3	3/8/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$3,907 )
2022	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	1	11/6/2021	SUPPLEMENT FOR EXPANSION	-$3,907
														Subtotal = -$3,907

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	2	9/20/2021	NON-COMPETING CONTINUATION	-$90,120
2021	2020	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	001	3	9/21/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$90,120
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $112,500 )
2020	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	2	8/18/2020	NON-COMPETING CONTINUATION	$112,500
														Subtotal = $112,500

Issue Date FY: 2019 ( Subtotal = $141,650 )
2019	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	001	1	3/20/2019	SUPPLEMENT FOR EXPANSION	$141,650
2019	2018	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	1	3/20/2019	NEW	$0
														Subtotal = $141,650

Issue Date FY: 2018 ( Subtotal = $112,500 )
2018	2018	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	1	9/10/2018	NEW	$112,500
														Subtotal = $112,500

Grand Total All Awards = $362,743

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository

Award Number: R21HL140268

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/17/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer