Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Illuminating the understudied druggable kinome through human phenotypes and model organisms

Award Number: R21HG010392
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2023

Group Awards By:

View Award Description

Illuminating the understudied druggable kinome through human phenotypes and model organisms - PROJECT SUMMARY Despite the widely recognized importance of kinases in human biology, a significant portion of the human kinome remains poorly characterized. A systematic means of identifying connections between understudied kinases and human physiology could have a transformative effect on human health. One approach is to leverage emerging genomic datasets and mine for associations between specific gene sets and diseases or clinical traits. However, the mechanisms by which variants contribute to the disease process are often unclear, especially in the case of understudied genes. Therefore, integration of complementary methods is required to frame these genes into biochemical pathways and to begin to understand the mechanisms by which they contribute to human physiology. To bridge this gap, we have integrated genetic information with blood levels of metabolites and proteins (~5,000 analytes) to begin to establish the genetic architecture of the human metabolome and proteome. As highlighted in the present proposal, our compendium of gene-analyte associations can also be leveraged for focused interrogations of specific gene sets to create biochemical signatures of metabolites or proteins “downstream” of common or rare genetic variants. In this proposal, we will generate biochemical signatures of genetic variation in the understudied kinases (Aim 1). Theses biochemical signatures will highlight potential new metabolic pathways regulated by kinase biology that can then be validated and studied by genetic manipulation in model systems. In Aim 2, we will use deep phenotyping studies in model organisms to illuminate the biological underpinnings of gene-analyte associations. Further, based on recent proof-of-concept findings, we will test the specific hypothesis that the poorly characterized kinase, CAMK1D, modulates triglyceride metabolism in vivo. Successful completion of these aims will provide opportunities to understand the biological functions of understudied kinases and will provide novel mechanistic insights into the biology they regulate. Further, this proposal will provide a strong foundation in the application of emerging “multi-omics” approaches to a new investigator and will lay the groundwork for a subsequent R01 application to use this pipeline to study a range of understudied genes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	000	2	11/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	000	2	10/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $218,750 )
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	000	2	8/28/2020	NON-COMPETING CONTINUATION	$218,750
														Subtotal = $218,750

Issue Date FY: 2019 ( Subtotal = $232,500 )
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	000	1	8/20/2019	NEW	$232,500
														Subtotal = $232,500

Grand Total All Awards = $451,250

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Illuminating the understudied druggable kinome through human phenotypes and model organisms

Award Number: R21HG010392

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer