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Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis

Award Number: R21HD119928
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis - Endometriosis is characterized by the extraneous presence of endometrial cells outside the uterine organ. The molecular mechanisms governing the migration of endometrial cells and the corresponding regulators of endometriosis are yet to be known, leaving critical gaps in the search for targets that can be used to treat endometriosis. We have recently found that an N-linked glycoprotein called basigin contributes to endometriosis. Here, we will apply proximity labeling technologies to define the interactome of basigin in cell culture models of endometriosis. Given the density of glycan post-translational modifications on basigin, we also reason that N-linked glycosylation can contribute to its interactome. The resulting interactomes will be used to define how basigin is regulating endometriosis and also open new potential targets for intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $506,000 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Child Health and Human Development Extramural Research	000	1	7/23/2025	NEW	$506,000
														Subtotal = $506,000

Grand Total All Awards = $506,000

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Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis

Award Number: R21HD119928

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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