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Tools and Methods for the Elucidation of Fatty Acid Amide Cell Signaling Pathways

Award Number: R21GM140390
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/05/2020
PERIOD OF PERFORMANCE END DATE: 11/30/2023

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Tools and Methods for the Elucidation of Fatty Acid Amide Cell Signaling Pathways - Abstract: Cell signaling is one of the most fundamental processes that controls human health, and yet the mechanics of this intricate system is largely unappreciated. This is stunning because the primary agents for this system, membrane receptors, are known to account for approximately 1/3 of all approved human drugs. Often, the receptors themselves are known before the discovery of their endogenous ligands. In this proposal, we detail a systematic method for the identification of the targets of fatty acid amides, a highly regulated class of molecules known to engage in at least two signaling processes. The bulk of the other members of this class of compounds have never been paired with their receptors, and uncovering this information has tremendous potential for identifying new therapeutic targets and improving drug discovery efforts by revealing potentially undesirable off-target candidates.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$27,269 )
2024	2022	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Biomedical Research and Research Training	000	2	5/13/2024	NON-COMPETING CONTINUATION	-$27,269
														Subtotal = -$27,269

Issue Date FY: 2022 ( Subtotal = $176,624 )
2022	2022	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Biomedical Research and Research Training	001	2	6/21/2022	NON-COMPETING CONTINUATION	$17,663
2022	2022	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Biomedical Research and Research Training	000	2	11/23/2021	NON-COMPETING CONTINUATION	$158,961
														Subtotal = $176,624

Issue Date FY: 2021 ( Subtotal = $213,999 )
2021	2021	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Biomedical Research and Research Training	000	1	12/1/2020	NEW	$213,999
														Subtotal = $213,999

Grand Total All Awards = $363,354

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Tools and Methods for the Elucidation of Fatty Acid Amide Cell Signaling Pathways

Award Number: R21GM140390

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/05/2020

PERIOD OF PERFORMANCE END DATE: 11/30/2023

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