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Clinical Neuropsychological Assessment Combined with Mobile Eye Tracking to Inform Diagnosis in Cerebral Visual Impairment

Award Number: R21EY038960
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Clinical Neuropsychological Assessment Combined with Mobile Eye Tracking to Inform Diagnosis in Cerebral Visual Impairment - Summary Cerebral (cortical) visual impairment (CVI) is a brain-based visual disorder caused by early neurodevelopmental injury and maldevelopment of visual processing pathways. It is currently the leading cause of pediatric visual impairment in the United States and other industrialized nations. The clinical profile of CVI is heterogeneous and complex, encompassing both lower-order visual deficits such as reduced visual acuity as well as higher-order visual perceptual deficits related to impaired visuospatial processing, object identification, deployment of attention, and visuomotor integration. These latter higher-order visual dysfunctions are a core feature of the condition and manifest even when lower-order functions are within normal range. In the clinical setting, standard ophthalmic examinations only assess lower-order visual functions and thus do not capture visual perceptual and processing deficits associated with CVI. Therefore, it is essential to objectively characterize the visuoperceptual profile of these individuals in order to support diagnosis, identify strengths and challenges, and inform (re)habilitative strategies. The overarching goal of this study is to develop and validate a testing battery designed to characterize the visuoperceptual profile of CVI compared to controls with neurotypical development and test-specific normative data. Based on recommendations drawn from focus group studies, this testing battery is comprised of five standardized neuropsychological assessments focused on evaluating visual scanning, planning, and processing speed as well as visuomotor integration abilities. During testing, we will integrate mobile (i.e., wearable, head-mounted) eye tracking to gain insight into real- time dynamics and behavioral processing strategies associated with differential task performance on these assessments. Gaze data will also be used to train an artificial neural network to identify key clusters of visuoperceptual impairments in CVI. Furthermore, machine learning will be employed to validate the discriminative value of our neuropsychological testing battery in identifying individuals with CVI. This rigorous evaluation will enable clinicians to select and combine various neuropsychological measures when assessing patients suspected of having CVI.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $467,277 )
2026	2026	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Vision Research	000	1	7/1/2026	NEW	$467,277
														Subtotal = $467,277

Grand Total All Awards = $467,277

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Clinical Neuropsychological Assessment Combined with Mobile Eye Tracking to Inform Diagnosis in Cerebral Visual Impairment

Award Number: R21EY038960

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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