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Arsenite-induced necroptosis

Award Number: R21ES030838
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2023

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Arsenite-induced necroptosis - Necroptosis is a recently identified caspase-independent cell death pathway that has been shown to act downstream of death receptor signaling or virus infection. Virus infection can be sensed by the host pattern recognition receptor, DAI, which leads to a cascade of events leading to rapid explosive cell death, as a way to prevent virus replication. We have recently shown that DAI not only senses virus infection, but also senses arsenite-induced stress, leading to necroptotic cell death. This broadens the potential importance of DAI mediated necroptosis, well beyond sensing of virus infection, to sensing of virus infection as only one example of stress that can be sensed by DAI. This proposal will better characterize the role of DAI in sensing stress and leading to necroptotic death, and will ask if this pathway is active in primary cells, that have been linked to potential stress-induced necroptosis in vivo. As a developmental proposal this work will justify a larger investment of resources in asking if stress-induced necroptotic death is involved in neurodegenerative, and skin diseases, and in tissue damage associated with ischemia and reperfusion.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Environmental Health	000	2	5/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $189,761 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Environmental Health	000	2	8/5/2022	NON-COMPETING CONTINUATION	$189,761
														Subtotal = $189,761

Issue Date FY: 2021 ( Subtotal = $229,492 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Environmental Health	000	1	9/22/2021	NEW	$229,492
														Subtotal = $229,492

Grand Total All Awards = $419,253

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Arsenite-induced necroptosis

Award Number: R21ES030838

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2023

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