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New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers

Award Number: R21EB036153
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers - SUMMARY Laser scanning microscopy (LSM) – including optical coherence tomography (OCT), confocal and multiphoton microscopy (MPM) – allows imaging thick, living tissue at depth, and thus has been widely adopted for many biological contexts. To facilitate further research and discovery, increase in the total information capacity with larger fields-of-view, faster imaging, or deeper penetration is desired, but is ultimately limited by tissue heating. This project will employ distributed amplification in optical fibers – a technique pioneered and honed for telecommunications – in order to bypass this limitation. Two fiber-based amplifier and detection systems (F- BADS) will be constructed leveraging both the sensitivity of optical amplification, and the bandwidth and dynamic range of photodiode detectors in order to increase the signal-to-noise ratio (SNR) and acquisition speed of LSM by ~100-fold relative to conventional detection modalities. The first F-BADS will employ Raman amplification in multi-mode fibers to provide gain in the visible spectrum. The module will be installed into an existing two-photon microscope and characterize the benefits in SNR and speed afforded by this technique relative to photo- multiplier-tube-based detection. The second F-BADS will use four-wave mixing in single-mode fiber (SMF) to provide gain in the 13XX tissue transparency window. The SMF-based design of this amplifier will facilitate alignment-free integration into a fiber-based reflectance microscope. SNR, speed, and penetration depth achievable with this method will be characterized for both confocal microscopy and OCT. Both proposed F-BADS are drop-in compatible as add-on modules for any microscope, and can amplify spatially coherent or incoherent light across the visible and near-infrared spectrum, including broadband fluorescent signals. Therefore, these proof-of-principle demonstrations of the utility of nonlinear fiber optical amplification will encourage wide adoption for a broad range of optical imaging applications, as well as facilitate further scaling of LSM information capacity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $211,875 )
2026	2026	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	5/28/2026	NON-COMPETING CONTINUATION	$211,875
														Subtotal = $211,875

Issue Date FY: 2025 ( Subtotal = $211,875 )
2025	2025	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	5/8/2025	NON-COMPETING CONTINUATION	$211,875
2025	2024	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	12/13/2024	NEW	-$221,662
2025	2024	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	1	5/20/2025	NEW	$0
2025	2024	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	12/13/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$221,662
														Subtotal = $211,875

Issue Date FY: 2024 ( Subtotal = $241,000 )
2024	2024	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/22/2024	NEW	$241,000
														Subtotal = $241,000

Grand Total All Awards = $664,750

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New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers

Award Number: R21EB036153

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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