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Quantitative assessment of autologous fat grafting in breast cancer treatment using 3D imaging

Award Number: R21EB035242
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Quantitative assessment of autologous fat grafting in breast cancer treatment using 3D imaging - Project Abstract Autologous fat grafting (AFG) is a procedure whereby adipose tissue is processed and transferred from one part of the body to another to add volume and address contour irregularity in soft tissue reconstruction. Anecdotally, we see improvement in tissue fibrosis and pain with standard grafting after radiation treatment indicating more than just a volume benefit of AFG. We have recently discovered that the transferred fat or adipose brings in healthy progenitor cells, growth factors and immune cells helpful in tissue regeneration and repair. Thus, purified graft is effectively a biological scaffold which can be modified to direct tissue healing or targeted therapies. One of the hurdles to clinical translation is the variability in graft retention and our ability to follow the graft over time. The long-term goal of our research is to investigate the capacity of engineered adipose grafts to improve clinical outcomes by mitigating inflammation and promoting graft retention. We propose a feasibility study investigating a novel imaging platform to quantitatively assess the overall volume and three-dimensional (3D) shape of the breast after fat grafting in cancer treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $242,493 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/28/2025	NON-COMPETING CONTINUATION	$242,493
														Subtotal = $242,493

Issue Date FY: 2024 ( Subtotal = $217,493 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	2/22/2024	NEW	$195,744
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	6/6/2024	NEW	$21,749
														Subtotal = $217,493

Grand Total All Awards = $459,986

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Quantitative assessment of autologous fat grafting in breast cancer treatment using 3D imaging

Award Number: R21EB035242

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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