Friday, April 26, 2024 4/26/2024

Automated MRI-based 3D Contractility (Strain) Analysis for Detecting Subclinical Cardiotoxicity in Breast Cancer Patients Undergoing Chemotherapy

Award Number: R21EB028063
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Project Summary Chemotherapy has made remarkable advances in the treatment of solid malignancies which cure millions of patients from breast cancer. However, the adverse effects of cardiotoxicity mediated by dose-dependent chemotherapeutic agents (such as anthracyclines) limit the efficacy of these therapies, causing left-ventricular (LV) dysfunction in the form of cardiomyopathies and even heart failure. Emerging evidence now suggest that early, myocardial strain-based, subclinical detection of cardiotoxicity may facilitate timely interventions in treatment management and therefore slow the progress of LV dysfunction and lower the incidence of heart failure. Recent clinical studies also show that the strain-based approach to detecting subclinical cardiotoxicity is superior to detections based on measuring differentials in LV ejection fraction (LVEF). The primary objective of this study is to create a highly automated, diagnostic application with an intuitive user-interface for computation of MRI-based myocardial contractile metrics in the LV in general, and to specifically use it in this study towards predicting the onset of subclinical cardiotoxicity in breast cancer patients. A parallel and equally important goal will involve demonstrating that regional contractile metrics (Lagrangian radial, circumferential and longitudinal normal strains, circumferential-radial and circumferential-longitudinal shear strains as well as twist and torsion) can predict cardiotoxicity prior to LVEF. Among the above mentioned 3D contractile metrics monitored, there will be an emphasis on our main hypothesis that torsion, which parameterizes the base-to-apex twisting motion of myofibers, is pivotal for indicating myocardial dysfunction. The source of data for these metrics will be the cardiac motion (displacements) recorded with the phase encoding MRI sequence of navigator-gated, spiral cine DENSE. Ultimately, the originality of this study will lie in our ability to fully automate the contractility measurement process including computations of 3D LV boundaries using a combination of image quantization and phase-unwrapping the DENSE data, in addition to the pointwise computation of the contractile metrics in a 3D myocardial grid of the patient’s LV using the DENSE displacements. The surveillance in each patient will be conducted at baseline (initiation of chemotherapy) and during regular follow-up investigations to determine the role that regional strain-based contractile metrics may have in detecting subclinical cardiotoxicity prior to LVEF. If established, the proof of concept for this early detection will be provided with intra-parametric and inter-parametric analysis of variance models, within and between the regional contractile metrics and LVEF and their correlations to clinical data conducted after two follow-up investigations performed on the enrolled chemotherapy patients. The ultimate goal is that this novel, contractility-based surveillance tool can provide cardio- oncologists with the direct ability to diagnose subclinical cardiotoxicity induced by chemotherapeutic agents and hence, the opportunity to intervene with cardio-protective therapy towards better treatment management.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$170,618 )
2024	2021	UNIVERSITY OF SOUTH ALABAMA	307 N UNIVERSITY BLVD	MOBILE	AL	36608	MOBILE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/25/2024	NON-COMPETING CONTINUATION	-$170,618
														Subtotal = -$170,618

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF SOUTH ALABAMA	307 UNIVERISTY BLVD 380 ADMINISTRATION BLDG	MOBILE	AL	36688	MOBILE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/17/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $172,944 )
2021	2021	UNIVERSITY OF SOUTH ALABAMA	307 UNIVERISTY BLVD 380 ADMINISTRATION BLDG	MOBILE	AL	36688	MOBILE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	6/9/2021	NON-COMPETING CONTINUATION	$172,944
														Subtotal = $172,944

Issue Date FY: 2020 ( Subtotal = $172,944 )
2020	2020	UNIVERSITY OF SOUTH ALABAMA	307 UNIVERISTY BLVD 380 ADMINISTRATION BLDG	MOBILE	AL	36688	MOBILE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/28/2020	NON-COMPETING CONTINUATION	$172,944
														Subtotal = $172,944

Issue Date FY: 2019 ( Subtotal = $208,194 )
2019	2019	UNIVERSITY OF SOUTH ALABAMA	307 UNIVERISTY BLVD 380 ADMINISTRATION BLDG	MOBILE	AL	36688	MOBILE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/5/2019	NEW	$208,194
														Subtotal = $208,194

Grand Total All Awards = $383,464

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Automated MRI-based 3D Contractility (Strain) Analysis for Detecting Subclinical Cardiotoxicity in Breast Cancer Patients Undergoing Chemotherapy

Award Number: R21EB028063

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer