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Measurement of Neuroexcitation during Bladder Filling: A Novel Metric for Overactive Bladder Phenotyping

Award Number: R21DK128649
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/25/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Measurement of Neuroexcitation during Bladder Filling: A Novel Metric for Overactive Bladder Phenotyping - Project Summary: Overactive Bladder (OAB), defined mainly by the symptom of urinary urgency, is a multifactorial condition, affecting more than 25% of the population. Because urgency is the brain's interpretation of multifactorial events, it is important to understand areas of brain activation that occur during bladder filling. Recently, there has been a growing body of research using functional MRI (fMRI) to identify brain regions and pathways associated with OAB. However, fMRI is expensive, time-consuming, and requires highly-specialized experts. Thus, a critical research objective is the development of office-based neuroimaging technologies to improve OAB phenotyping. Our multi-disciplinary research group combining urology, engineering, and neuroimaging expertise has made advances in the development of novel office-based technologies for OAB evaluation. We created a real-time Sensation Meter used during bladder filling. We also developed a novel functional Brain NIRS (fNIRS) protocol that shows localized regions of cortical neuroexcitation in response to bladder filling. Our hypothesis is that fNIRS can be used to identify different patterns of OAB representing new phenotypic subtypes. We will test our hypothesis in two aims. In the first aim, we will identify patterns of neuroexcitation with fNIRS during natural bladder filling in normal men and women with OAB using our established 3-fill hydration protocol. We will then use this information to evaluate age-matched women with OAB. The second aim will compare patterns of neuroexcitation with fNIRS and fMRI during natural bladder filling in women with OAB. Successful completion of this proposal will create new office-based neuroimaging technology using fNIRS that, in combination with our established sensation meter and hydration protocols, can ultimately be used for improved phenotyping of OAB in future studies. The data from this study will be used in subsequent multi-PI R01 proposals to test our fNIRS technology on larger participant groups with varying forms of voiding dysfunction and also to study the acute and chronic effects of OAB treatments on sensation and neuroimaging pathways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $177,689 )
2022	2022	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	8/2/2022	NON-COMPETING CONTINUATION	$177,689
2022	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	12/16/2021	NEW	$0
														Subtotal = $177,689

Issue Date FY: 2021 ( Subtotal = $227,646 )
2021	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/25/2021	NEW	$227,646
														Subtotal = $227,646

Grand Total All Awards = $405,335

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Measurement of Neuroexcitation during Bladder Filling: A Novel Metric for Overactive Bladder Phenotyping

Award Number: R21DK128649

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/25/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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