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Impact of SARS-CoV-2 mediated salivary gland dysfunction on secreted salivary antimicrobial peptides and the risk for oral opportunistic infections

Award Number: R21DE031888
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Impact of SARS-CoV-2 mediated salivary gland dysfunction on secreted salivary antimicrobial peptides and the risk for oral opportunistic infections - PROJECT SUMMARY Recently, individuals with COVID-19 were found to harbor replicating SARS-CoV-2 inside salivary epithelial cells resulting in inflammation, architectural distortion, and atrophy of minor and major salivary glands. We have previously demonstrated the importance of histatin-5, a secreted salivary antimicrobial peptide exclusively produced in the salivary glands, in protecting the oral cavity against the opportunistic pathogen Candida albicans. In light of the findings indicating that COVID-19 patients likely suffer from salivary gland dysfunction, we hypothesize that histatin-5 salivary levels are compromised in COVID-19 patients potentially predisposing these individuals to long term opportunistic infections and other oral mucosal conditions. In this proposed clinical study, we will utilize our developed immunoassay to demonstrate the impact of COVID-19 on histatin-5 production, Candida colonization, and induction of local immune activation. We expect the findings generated from these studies to provide lacking mechanistic insights into the pathophysiology of salivary gland dysfunction in COVID-19 patients, and its implications on the health of the oral cavity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	2	3/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $193,125 )
2023	2023	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	2	3/22/2023	NON-COMPETING CONTINUATION	$193,125
														Subtotal = $193,125

Issue Date FY: 2022 ( Subtotal = $231,750 )
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	1	3/18/2022	NEW	$231,750
														Subtotal = $231,750

Grand Total All Awards = $424,875

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Impact of SARS-CoV-2 mediated salivary gland dysfunction on secreted salivary antimicrobial peptides and the risk for oral opportunistic infections

Award Number: R21DE031888

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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