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More Than Mechanical Retention: Characterization of Lactobacillus Clinical Strains Using In Vitro Models

Award Number: R21DE031856
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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More Than Mechanical Retention: Characterization of Lactobacillus Clinical Strains Using In Vitro Models - SUMMARY Dental caries remains among the most prevalent infectious disease worldwide, costing USA tens of billions of dollars annually in associated care and productivity losses. Dental caries is a result of imbalance of the indigenous microbiota on the tooth surface known as dental plaque, and the acidic metabolites of bacterial metabolism are directly linked to the disease development. It is well understood that conditions like continuous consumption of fermentable sugars, especially sucrose and saliva deficiency favor the emergency of a highly acidogenic and aciduric plaque microbiota, which include Streptococcus mutans and lactobacilli. Lactobacillus (Lb) sp. were the first implicated in dental caries over a century ago, but major gaps remain in knowledge concerning how the different Lb sp. establish and persist in the plaque microbiota and promote the development of carious lesions. In this study, a collection of hundreds of different clinical Lb isolates will be examined using well established in vitro models to elucidate how major groups of Lb sp. colonize and establish on a surface; how S. mutans and environmental conditions may modulate the ability of major Lb sp. to establish and compete in a mixed-species consortium; and how interactions between S. mutans and major Lb sp. influence the community dynamics under conditions typical of the oral cavity. It is highly anticipated that the results from this study will lead to novel insights on each of these aspects and the roles of oral Lb in plaque microbiota and dental caries. Together, the information derived from this study should also serve as a foundation for further investigation on the pathophysiology of oral Lb, the plaque biofilm ecology, and the development of novel strategies against dental caries and other conditions where dysbiotic microbiota is a major underlying factor.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $221,250 )
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Oral Diseases and Disorders Research	001	2	6/4/2024	NON-COMPETING CONTINUATION	$22,125
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Oral Diseases and Disorders Research	000	2	12/21/2023	NON-COMPETING CONTINUATION	$199,125
														Subtotal = $221,250

Issue Date FY: 2023 ( Subtotal = $222,750 )
2023	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Oral Diseases and Disorders Research	000	1	12/29/2022	NEW	$222,750
														Subtotal = $222,750

Grand Total All Awards = $444,000

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More Than Mechanical Retention: Characterization of Lactobacillus Clinical Strains Using In Vitro Models

Award Number: R21DE031856

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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