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Electrophysiological correlates of language processing in minimally verbal children with ASD: Elucidating pathways to language impairment

Award Number: R21DC017834
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Electrophysiological correlates of language processing in minimally verbal children with ASD: Elucidating pathways to language impairment - Project Abstract ASD is estimated to occur in 1.6% of children (CDC, 2014), and approximately 30% of the ASD population remains minimally verbal (MV). This MV portion of the population experiences considerable clinical impairment and requires intensive intervention that often fails to achieve improved outcomes. Relatively little research focuses on understanding why these children fail to gain language. As a psychologist and translational researcher, my work focuses on identifying the mechanisms underlying language impairment in ASD, in order to better predict developmental trajectories and individualize intervention. The proposed study will use EEG to (1) measure multiple facets of language processing in order to assess causes of language impairment in MV children with ASD; (2) analyze spectral components of the EEG signal in order to reveal possible biological mechanisms influencing language development in ASD; and (3) use advanced biostatistics methods specifically developed for analyzing rich, multifaceted datasets such as what is yielded by EEG recording. This level of rigorous inference will be instrumental in discovering neurobiological traits that underlie heterogeneity in ASD. Very few electrophysiology studies have included MV participants, likely due to the difficulties inherent in working with that population. Findings from this study will form the foundation for my application for an NIH R01 award, focused on discovering how these EEG biomarkers of language impairment in children with ASD are related to developmental trajectories and progress in intervention. My long-term academic career will target this underserved population, improving outcomes by understanding neural mechanisms underlying language impairment and contributing to the development of mechanism-based, individualized intervention strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	3	11/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $169,500 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	3	1/14/2023	NON-COMPETING CONTINUATION	$16,950
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	3	11/10/2022	NON-COMPETING CONTINUATION	$152,550
														Subtotal = $169,500

Issue Date FY: 2022 ( Subtotal = $169,500 )
2022	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	2	4/27/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$169,500
2022	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	003	2	7/13/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$95,326
2022	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	002	1	7/13/2022	NEW	-$95,326
2022	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	1	4/27/2022	NEW	$0
														Subtotal = $169,500

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	1	9/17/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $156,000 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	1	4/15/2020	NEW	$156,000
														Subtotal = $156,000

Grand Total All Awards = $495,000

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Electrophysiological correlates of language processing in minimally verbal children with ASD: Elucidating pathways to language impairment

Award Number: R21DC017834

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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