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Heating Magnetic Nanoparticles using Low Frequency Ferromagnetic Resonance

Award Number: R21CA297246
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Heating Magnetic Nanoparticles using Low Frequency Ferromagnetic Resonance - Project Summary: Several cancer therapies involve inducing heat in the disease: ablation and heat released drugs are but a few of them. Many of these therapies use magnetic fields to heat magnetic nanoparticles. The most significant limitation is the trade-off between energy deposition in the nanoparticles and penetration into normal tissue. Higher frequency magnetic fields deposit more energy in the nanoparticles but have much higher absorption in normal tissue so the normal tissue is heated rather than the nanoparticles in the cancer. We propose a nanoparticle heating system that adds a very low frequency alternating magnetic field producing lower frequency pulsed RF fields to deposit more energy into the nanoparticles. The pulsed RF will be delivered at the ferromagnetic resonant frequency of the nanoparticles to deposit energy into the nanoparticles very efficiently. The very low frequency magnetic field will reduce the Larmor frequency of the ferromagnetic resonance to a frequency selected to mitigate heating of surrounding normal tissue.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $226,704 )
2025	2025	DARTMOUTH-HITCHCOCK CLINIC	1 MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cancer Treatment Research	000	1	12/20/2024	NEW	$226,704
														Subtotal = $226,704

Grand Total All Awards = $226,704

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Heating Magnetic Nanoparticles using Low Frequency Ferromagnetic Resonance

Award Number: R21CA297246

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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