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The efferent synapse in enteroendocrine cells

Award Number: R21AT010818
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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The efferent synapse in enteroendocrine cells - Abstract. The long-term goal of our parent research program is to document how the gastrointestinal (GI) tract transduces luminal signals to the brain via peripheral nerves and how these nerves modulate GI sensory function. The goal of this US-Japan BRPC administrative supplement is for Dr. Diego Bohórquez (parent grant P.I) who is a neuroscientist at Duke University (Durham, NC, USA) to visit Dr. Michael Huffman who is a primate behaviorist at the Primate Research Institute of Kyoto University (Nagoya, Japan). The goal of the visit is to acquire advanced research skills and start to conduct collaborative research to uncover the neural basis of self-medication. In particular, and related to the goals of the R21AT010818 NIH-NCCIH parent grant “The efferent synapse in enteroendocrine cells”, the visit will have two specific aims: 1. To learn the scientific methodology used to study self-medication in primates in the field at the Primate Research Institute. 2. To identify potential medicinal plants and compounds to test back at Duke University. Once characterized these compounds could be used to alleviated behavioral disorders by targeting gut sensory function. By learning how self-medicating behaviors are identified and studied in the wild, we will be able to translate that work to our laboratory. Moreover, by identifying plants with medicinal values, these compounds could be used to modulate gut sensory function in an effort to treat behavioral disorders by modulating gut sensory function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$2,887 )
2025	2021	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Research and Training in Complementary and Integrative Health	000	2	12/23/2024	SUPPLEMENT FOR EXPANSION	-$2,887
														Subtotal = -$2,887

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Research and Training in Complementary and Integrative Health	001	2	11/6/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2020	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Research and Training in Complementary and Integrative Health	000	2	11/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	001	2	9/16/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	000	2	9/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $40,250 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	000	2	1/12/2021	SUPPLEMENT FOR EXPANSION	$40,250
														Subtotal = $40,250

Issue Date FY: 2020 ( Subtotal = $201,250 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	002	2	8/18/2020	NON-COMPETING CONTINUATION	$201,250
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	004	2	8/31/2020	NON-COMPETING CONTINUATION	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	003	1	8/29/2020	NEW	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	001	1	1/15/2020	NEW	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	000	1	11/7/2019	NEW	$0
														Subtotal = $201,250

Issue Date FY: 2019 ( Subtotal = $241,500 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Research and Training in Complementary and Integrative Health	000	1	9/14/2019	NEW	$241,500
														Subtotal = $241,500

Grand Total All Awards = $480,113

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The efferent synapse in enteroendocrine cells

Award Number: R21AT010818

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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