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METABOLIC NEUROPROTECTION:CREATINE SUPPLEMENTATION IN HUMAN BRAIN

Award Number: R21AT002984
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2005
PERIOD OF PERFORMANCE END DATE: 05/31/2008

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METABOLIC NEUROPROTECTION:CREATINE SUPPLEMENTATION IN HUMAN BRAIN - DESCRIPTION (provided by applicant): Oral creatine supplementation has been demonstrated by several groups to increase muscle performance and mass. High concentrations of PCr and creatine are also found in the brain, which with its relatively high oxygen consumption means that, similar to muscle, brain tissue may be metabolically affected by exogenous creatine. However while there is extensive work examining how use of creatine affects muscle performance, there is relatively less work available in the brain. In this proposal we will begin to fill this gap, with non-invasive MR measurements of high energy phosphates, NAA, creatine and perfusion/oxidative metabolism in healthy controls. Furthermore, because of the increasing data that progressive metabolic dysfunction may contribute directly to the pathophysiology of epilepsy, we will also examine the metabolic and clinical effects of oral creatine supplementation in patients with temporal lobe epilepsy. This work is done in collaboration with R. Kuzniecky , MD with the NYU Comprehensive Epilepsy Center. In particular, epilepsy is known to respond to another form of "metabolic therapy", the high fat ketogenic diet. As we have previously shown using MR spectroscopy, patients placed on the ketogenic diet demonstrated increases in cerebral PCr/ATP, known to be decreased in epilepsy patients. If successful, this project may show that creatine 1) can provide a supplementary avenue of therapy and 2) contribute additional evidence for a metabolic pathophysiologic component to epilepsy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $117,026 )
2007	2007	YALE UNIVERSITY, SCHOOL OF MEDICINE	451 COLLEGE STREET, POB 1931	NEW HAVEN	CT	06409		USA	Research and Training in Complementary and Integrative Health	000	3	5/16/2007	NON-COMPETING CONTINUATION	$117,026
														Subtotal = $117,026

Issue Date FY: 2006 ( Subtotal = $296,665 )
2006	2006	YALE UNIVERSITY, SCHOOL OF MEDICINE	451 COLLEGE STREET, POB 1931	NEW HAVEN	CT	06409		USA	Research and Training in Complementary and Integrative Health	000	2	9/18/2006	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$296,665
														Subtotal = $296,665

Issue Date FY: 2005 ( Subtotal = $247,375 )
2005	2005	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	500 WEST 185TH STREET	NEW YORK-NEW YORK	NY	10033		USA	Research and Training in Complementary and Integrative Health	000	1	7/20/2005	NEW	$247,375
														Subtotal = $247,375

Grand Total All Awards = $661,066

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METABOLIC NEUROPROTECTION:CREATINE SUPPLEMENTATION IN HUMAN BRAIN

Award Number: R21AT002984

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2005

PERIOD OF PERFORMANCE END DATE: 05/31/2008

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